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SecreFlo™ (secretin) is a pure sterile, nonpyrogenic, lyophilized white cake powder acetate salt of secretin, a peptide hormone. Secretin has an amino acid sequence identical to the naturally occurring porcine secretin consisting of 27 amino acids.

Secretin is chemically defined as follows:

Molecular Weight: 3055.5

Empirical Formula: C₁₃₀H₂₂₀N₄₄O₄₁

Structural Formula:

H-His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Asp-Ser- Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH₂

SecreFlo™ contains 16 mcg of purified secretin, 15 mg of L-cysteine hydrochloride, and 20 mg of mannitol per vial. When reconstituted in 8 mL of Sodium Chloride Injection USP, each mL of solution contains 2 mcg secretin for intravenous use. The pH of the reconstituted solution has a range of 3-6.5.

Last reviewed on RxList: 11/21/2008
This monograph has been modified to include the generic and brand name in many instances.