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SecreFlo Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 6/8/2016

SecreFlo (secretin) is a peptide hormone used in stimulating pancreatic secretions, including bicarbonate, to aid in the diagnosis of pancreatic exocrine dysfunction, to stimulate gastrin secretion to aid in the diagnosis of gastrinoma, and to stimulate pancreatic secretions to facilitate the identification of the ampulla of Vater and accessory papilla during endoscopic retrograde cholangiopancreatography (ERCP). Common side effects of SecreFlo include:

  • abdominal discomfort
  • abdominal cramps
  • bloating
  • flushing
  • nausea
  • slow heart rate
  • low blood pressure
  • sweating
  • diarrhea
  • fatigue
  • fever
  • headache
  • feeling hot
  • hunger
  • lightheadedness
  •  numbness or tingling in extremities
  • pale skin (pallor)
  • rash
  • hives, and
  • vomiting

SecreFlo dose is determined by a physician. SecreFlo may interact with anticholinergic medications. Tell your doctor all medications and supplements you use. During pregnancy, SecreFlo should be used only if prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Our SecreFlo (secretin) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

SecreFlo FDA Prescribing Information: Side Effects
(Adverse Reactions)


Occasional mild adverse events have been noted in association with the use of SecreFlo™ (secretin) in clinical studies of over 957 patients and 24 volunteer subjects.


EVENT SecreFlo™ n = 981
Incidence (Patients)
Abdominal cramps 2 (2)
Abdominal discomfort 7 (7)
Bleeding - sphincterectomy 6 (6)
Bleeding - upper GI 2 to endoscopic abrasion 2 (2)
Bloating 1 (1)
Bradycardia (mild) 2 (2)
Burning in stomach 3 (2)
Decreased blood pressure 6 (5)
Diaphoresis 6 (4)
Diarrhea 1 (1)
Endoscopic perforation of pancreatic duct 2 (2)
Fatigue 1 (1)
Fever 1 (1)
Flushing 6 (5)
Headache 2 (2)
Hot Sensation 1 (1)
Hunger Pangs 1 (1)
Leukocytoplastic Vasculitis 1 (1)
Lightheaded 3 (2)
Nausea 8 (8)
Numbness/Tingling in extremeties 2 (1)
Pallor 1 (1)
Possible seizure 1 (1)
Rash -abdominal 1 (1)
Thready pulse 1 (1)
Transient low O2 saturation 1 (1)
Transient respiratory distress 2 (2)
Urticaria 2 contrast material (prior to secretin administration) 1 (1)
Vomiting 1 (1)
Total Patients with AE's (%) 73 (7.4)

Read the entire FDA prescribing information for SecreFlo (Secretin)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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