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Sectral (acebutolol) is well tolerated in properly selected patients. Most adverse reactions have been mild, not required discontinuation of therapy, and tended to decrease as duration of treatment increases. The following table shows the frequency of treatmentrelated side effects derived from controlled clinical trials in patients with hypertension, angina pectoris, and arrhythmia. These patients received Sectral (acebutolol) , propranolol, or hydrochlorothiazide as monotherapy, or placebo.
TOTAL VOLUNTEERED AND ELICITED (U.S. STUDIES)
| Body System/
|Sectral Propranolol Hydrochlorothiazide Placebo|
|Central Nervous System|
The following selected (potentially important) side effects were seen in up to 2% of Sectral (acebutolol) patients:
Central Nervous System: anxiety, hyper/hypoesthesia, impotence.
Gastrointestinal: vomiting, abdominal pain.
Liver and Biliary System: A small number of cases of liver abnormalities (increased SGOT, SGPT, LDH) have been reported in association with acebutolol therapy. In some cases increased bilirubin or alkaline phosphatase, fever, malaise, dark urine, anorexia, nausea, headache, and/or other symptoms have been reported. In some of the reported cases, the symptoms and signs were confirmed by rechallenge with acebutolol. The abnormalities were reversible upon cessation of acebutolol therapy.
Musculoskeletal: back pain, joint pain.
Autoimmune: In extremely rare instances, systemic lupus erythematosus has been reported.
The incidence of drug-related adverse effects (volunteered and solicited) according to Sectral (acebutolol) dose is shown below. (Data from 266 hypertensive patients treated for 3 months on a constant dose.)
|Body System|| 400 mg/day
| 1200 mg/day
|Central Nervous System||9%||13%||17%|
Potential Adverse Events
In addition, certain adverse effects not listed above have been reported with other β-blockingagents and should also be considered as potential adverse effects of Sectral (acebutolol) . Central Nervous System: Reversible mental depression progressing to catatonia (an acute syndrome characterized by disorientation for time and place), short-term memory loss, emotional lability, slightly clouded sensorium, and decreased performance (neuropsychometrics). Cardiovascular: Intensification of AV block (see CONTRAINDICATIONS).
Allergic: Erythematous rash, fever combined with aching and sore throat, laryngospasm, and respiratory distress.
Miscellaneous: Reversible alopecia and Peyronie's disease. The oculomucocutaneous syndrome associated with the β-blocker practolol has not been reported with Sectral (acebutolol) during investigational use and extensive foreign clinical experience.
Read the Sectral (acebutolol) Side Effects Center for a complete guide to possible side effects
Catecholamine-depleting drugs, such as reserpine, may have an additive effect when given with β-blocking agents. Patients treated with Sectral (acebutolol) plus catecholamine depletors should, therefore, be observed closely for evidence of marked bradycardia or hypotension which may present as vertigo, syncope/presyncope, or orthostatic changes in blood pressure without compensatory tachycardia. Exaggerated hypertensive responses have been reported from the combined use of β-adrenergic antagonists and a-adrenergic stimulants, including those contained in proprietary cold remedies and vasoconstrictive nasal drops. Patients receiving β-blockers should be warned of this potential hazard.
Blunting of the antihypertensive effect of beta-adrenoceptor blocking agents by nonsteroidal anti-inflammatory drugs has been reported. No significant interactions with digoxin, hydrochlorothiazide, hydralazine, sulfinpyrazone, oral contraceptives, tolbutamide, or warfarin have been observed.
Read the Sectral Drug Interactions Center for a complete guide to possible interactions
Last reviewed on RxList: 9/19/2007
This monograph has been modified to include the generic and brand name in many instances.
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