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Sectral

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Sectral

Sectral

Sectral Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Sectral (acebutolol hydrochloride) is used to treat hypertension (high blood pressure) and heart rhythm disorders. It is a beta-blocker. This medication is available in generic form. Common side effects include dizziness, lightheadedness, drowsiness, tiredness, constipation, diarrhea, stomach upset/gas, nausea, trouble sleeping or unusual dreams your body adjusts to the medication.

The initial dosage of Sectral in uncomplicated mild-to-moderate hypertension is 400 mg. The usual initial dose of Sectral to treat ventricular arrhythmia is 400 mg daily given as 200 mg twice daily. Dosage may be increased gradually until an optimal response is obtained, generally 600 to 1200 mg per day. Sectral may interact with allergy treatments (or allergy skin-testing), clonidine, guanabenz, MAO inhibitors, diabetes medications, heart medications, medicine for asthma or other breathing disorders, cold medicines, stimulant medicines, or diet pills. Tell your doctor all medications you use. Sectral should be used only when prescribed during pregnancy. Newborns whose mothers have taken this drug near the date of delivery may have problems such as low blood pressure, low heart rate and low birth weight, and may require special medical monitoring. This drug passes into breast milk. Consult your doctor before breast-feeding.

Our Sectral (acebutolol hydrochloride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Sectral in Detail - Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • slow or uneven heartbeats;
  • feeling light-headed, fainting;
  • feeling short of breath, even with mild exertion;
  • swelling of your ankles or feet;
  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • depression; or
  • cold feeling in your hands and feet.

Less serious side effects may include:

  • decreased sex drive, impotence, or difficulty having an orgasm;
  • sleep problems (insomnia);
  • tired feeling; or
  • anxiety, nervousness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Sectral (Acebutolol) »

What is Patient Information Overview?

A concise overview of the drug for the patient or caregiver from First DataBank.

Sectral Overview - Patient Information: Side Effects

SIDE EFFECTS: See also Warning and Precautions sections.

Tiredness, dizziness, lightheadedness, nausea, upset stomach, slow heartbeat, or trouble sleeping may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

This drug may reduce blood flow to your hands and feet, causing them to feel cold. Smoking may worsen this effect. Dress warmly and avoid tobacco use.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: symptoms of asthma (for example, feelings of tightness in the chest, shortness of breath, cough, wheezing), blue fingers/toes, fainting, very slow heartbeat, new or worsening symptoms of heart failure (such as swelling ankles/feet, severe tiredness, shortness of breath, unexplained/sudden weight gain), mental/mood changes (such as confusion, depression, memory problems), vision changes, symptoms of liver disease (such as dark urine, persistent nausea, vomiting, stomach/abdominal pain, yellowing eyes/skin).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Read the entire patient information overview for Sectral (Acebutolol)»

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Sectral FDA Prescribing Information: Side Effects
(Adverse Reactions)

SIDE EFFECTS

Sectral (acebutolol) is well tolerated in properly selected patients. Most adverse reactions have been mild, not required discontinuation of therapy, and tended to decrease as duration of treatment increases. The following table shows the frequency of treatmentrelated side effects derived from controlled clinical trials in patients with hypertension, angina pectoris, and arrhythmia. These patients received Sectral (acebutolol) , propranolol, or hydrochlorothiazide as monotherapy, or placebo.

TOTAL VOLUNTEERED AND ELICITED (U.S. STUDIES)

Body System/
Adverse Reaction
Sectral Propranolol Hydrochlorothiazide Placebo
(N=1002)
%
(N=424)
%
(N=178)
%
(N=314)
%
Cardiovascular        
Chest Pain 2 4 4 1
Edema 2 2 4 1
Central Nervous System        
Depression 2 1 3 1
Dizziness 6 7 12 2
Fatigue 11 17 10 4
Headache 6 9 13 4
Insomnia 3 6 5 1
Abnormal dreams 2 3 0 1
Dermatologic        
Rash 2 2 4 1
Gastrointestinal        
Constipation 4 2 7 0
Diarrhea 4 5 5 1
Dyspepsia 4 6 3 1
Flatulence 3 4 7 1
Nausea 4 6 3 0
Genitourinary        
Micturition (frequency) 3 1 9 <1
Musculoskeletal        
Arthralgia 2 1 3 2
Myalgia 2 1 4 0
Respiratory        
Cough 1 1 2 0
Dyspnea 4 6 4 2
Rhinitis 2 1 4 <1
Special Senses        
Abnormal Vision 2 2 3 0

The following selected (potentially important) side effects were seen in up to 2% of Sectral (acebutolol) patients:

Cardiovascular: hypotension, bradycardia, heart failure.

Central Nervous System: anxiety, hyper/hypoesthesia, impotence.

Dermatological: pruritus.

Gastrointestinal: vomiting, abdominal pain.

Genitourinary: dysuria, nocturia.

Liver and Biliary System: A small number of cases of liver abnormalities (increased SGOT, SGPT, LDH) have been reported in association with acebutolol therapy. In some cases increased bilirubin or alkaline phosphatase, fever, malaise, dark urine, anorexia, nausea, headache, and/or other symptoms have been reported. In some of the reported cases, the symptoms and signs were confirmed by rechallenge with acebutolol. The abnormalities were reversible upon cessation of acebutolol therapy.

Musculoskeletal: back pain, joint pain.

Respiratory: pharyngitis, wheezing.

Special Senses: conjunctivitis, dry eye, eye pain.

Autoimmune: In extremely rare instances, systemic lupus erythematosus has been reported.

The incidence of drug-related adverse effects (volunteered and solicited) according to Sectral (acebutolol) dose is shown below. (Data from 266 hypertensive patients treated for 3 months on a constant dose.)

Body System 400 mg/day
(N=132)
800 mg/day
(N=63)
1200 mg/day
(N=71)
Cardiovascular 5% 2% 1%
Gastrointestinal 3% 3% 1%
Musculoskeletal 2% 3% 4%
Central Nervous System 9% 13% 17%
Respiratory 1% 5% 6%
Skin 1% 2% 1%
Special Senses 2% 2% 6%
Genitourinary 2% 3% 1%

Potential Adverse Events

In addition, certain adverse effects not listed above have been reported with other β-blockingagents and should also be considered as potential adverse effects of Sectral (acebutolol) . Central Nervous System: Reversible mental depression progressing to catatonia (an acute syndrome characterized by disorientation for time and place), short-term memory loss, emotional lability, slightly clouded sensorium, and decreased performance (neuropsychometrics). Cardiovascular: Intensification of AV block (see CONTRAINDICATIONS).

Allergic: Erythematous rash, fever combined with aching and sore throat, laryngospasm, and respiratory distress.

Hematologic: Agranulocytosis, nonthrombocytopenic, and thrombocytopenic purpura.

Gastrointestinal: Mesenteric arterial thrombosis and ischemic colitis.

Miscellaneous: Reversible alopecia and Peyronie's disease. The oculomucocutaneous syndrome associated with the β-blocker practolol has not been reported with Sectral (acebutolol) during investigational use and extensive foreign clinical experience.

Read the entire FDA prescribing information for Sectral (Acebutolol) »

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Sectral - User Reviews

Sectral User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Sectral sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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