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Selseb Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 4/12/2016

Selseb (selenium sulfide 2.25%) shampoo is a liquid antiseborrheic, antifungal preparation for the treatment of seborrheic dermatitis of the scalp, dandruff, and tinea versicolor. Selseb is available in the generic form termed selenium sulfide. Side effects of Selseb include:

  • skin irritation
  • an increase in normal hair loss
  • discoloration of the hair
  • oiliness, and
  • dryness of the hair and scalp
Serious side effects of Selseb include allergic reactions and eye and skin irritation.

Each gram of Selseb Shampoo contains 22.5 mg selenium sulfide in a viscous suspension of 180 ml. Dosage for Selseb depends on the condition for which the shampoo was prescribed. For seborrheic dermatitis and dandruff: Generally 2 applications each week for 2 weeks will control symptoms. Subsequently, shampoo may be used less frequently - weekly, every 2 weeks, every 3 to 4 weeks or as directed by a physician. Selseb should not be applied more frequently than necessary to maintain control. For tinea versicolor: Apply to affected areas and lather with a small amount of water. Allow product to remain on skin for 10 minutes, then rinse thoroughly. Repeat procedure once a day for seven days or as directed by a physician. Selseb may interact with other topical medications. Tell your doctor all medications and supplements you use. It is also not known whether Selseb can cause fetal harm when applied to the body surfaces of a pregnant woman or can affect reproduction capacity. Under ordinary circumstances, Selseb should not be used by pregnant women. It is not known whether or not selenium sulfide is secreted in human milk. Because many drugs are secreted in human milk, caution should be exercised when Selseb is administered to a nursing woman. Safety and effectiveness in the pediatric has not been established for Selseb.

Our Selseb Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Selseb in Detail - Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using selenium sulfide and call your doctor if you have unusual or severe blistering, itching, redness, peeling, dryness, or irritation of the skin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Selseb (Selenium Sulfide 2.25%)

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Selseb FDA Prescribing Information: Side Effects
(Adverse Reactions)


In decreasing order of severity: skin irritation; occasional reports of increase in normal hair loss; discoloration of hair (can be avoided or minimized by thorough rinsing of hair after treatment). As with other shampoos, oiliness or dryness of hair and scalp may occur.

Read the entire FDA prescribing information for Selseb (Selenium Sulfide 2.25%)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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