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Sensipar

Introduction

Primary hyperparathyroidism is a disorder of the parathyroid glands, also called parathyroids. "Primary" means this disorder originates in the parathyroids: One or more enlarged, overactive parathyroid glands secretes too much parathyroid hormone (PTH). In secondary hyperparathyroidism, a problem such as kidney failure causes the parathyroids to be overactive. This publication focuses on primary hyperparathyroidism.

What are the parathyroid glands?

The parathyroid glands are four pea-sized glands located on the thyroid gland in the neck. Occasionally, a person is born with one or more of the parathyroid glands embedded in the thyroid, in the thymus, or located elsewhere around this area. In most such cases, however, the glands function normally.

Though their names are similar, the thyroid and parathyroid glands are entirely different glands, each producing distinct hormones with specific functions. The p...

Sensipar

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OVERDOSE

Doses titrated up to 300 mg once daily have been safely administered to patients on dialysis. Overdosage of Sensipar (cinacalcet) may lead to hypocalcemia. In the event of overdosage, patients should be monitored for signs and symptoms of hypocalcemia and appropriate measures taken to correct serum calcium levels [see WARNINGS AND PRECAUTIONS].

Since Sensipar (cinacalcet) is highly protein bound, hemodialysis is not an effective treatment for overdosage of Sensipar (cinacalcet) .

CONTRAINDICATIONS

Hypocalcemia: Sensipar (cinacalcet) treatment should not be initiated if serum calcium is less than the lower limit of the normal range [see WARNINGS AND PRECAUTIONS].

Last reviewed on RxList: 4/19/2011
This monograph has been modified to include the generic and brand name in many instances.

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