"Sometimes the juice ain't worth the squeeze... especially when combining grapefruit with medicines.
While it can be part of a balanced and nutritious diet, grapefruit can have serious consequences when taken with certain medications. Cu"...
(articaine HCl and epinephrine) Injection; Intraoral Submucosal Injection
Articaine hydrochloride 4% and epinephrine 1:200,000
Articaine hydrochloride 4% and epinephrine 1:100,000
- Patient Information:
Details with Side Effects
Septocaine® (articane hcl and epinephrine injection) injection is a sterile, aqueous solution that contains articaine HCl 4% (40 mg/mL) and epinephrine bitartrate in an epinephrine 1:200,000 or epinephrine 1:100,000 strength. Articaine HCl is an amino amide local anesthetic, chemically designated as 4-methyl-3-[2-(propylamino)-propionamido]-2-thiophenecarboxylic acid, methyl ester hydrochloride and is a racemic mixture. Articaine HCl has a molecular weight of 320.84 and the following structural formula:
Articaine HCl has a partition coefficient in n-octanol/Soerensen buffer (pH 7.35) of 17 and a pKa of 7.8.
Epinephrine bitartrate, (-)-1-(3,4-Dihydroxyphenyl)-2-methylamino-ethanol (+) tartrate (1:1) salt, is a vasoconstrictor that is added to articaine HCl in a concentration of 1:200,000 or 1:100,000 (expressed as free base). It has a molecular weight of 333.3 and the following structural formula:
Septocaine® (articane hcl and epinephrine injection) contains articaine HCl (40 mg/mL), epinephrine (1:200,000 or 1:100,000) (as epinephrine bitartrate), sodium chloride (1.6 mg/mL), and sodium metabisulfite (0.5 mg/mL). The product is formulated with a 15% overage of epinephrine. The pH is adjusted with sodium hydroxide.
What are the possible side effects of articaine and epinephrine (Septocaine)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling or puffiness of your face, lips, tongue, or throat.
Tell your caregivers at once if you have a serious side effect such as:
- weak or shallow breathing;
- slow heart rate, weak pulse;
- feeling like you might pass out;
- swelling in your face;
- swollen or bleeding gums;
- anxiety, confusion, restless feeling, tremors or shaking;
- blurred vision, ringing in your ears; or
Last reviewed on RxList: 3/12/2010
This monograph has been modified to include the generic and brand name in many instances.
Additional Septocaine Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Find out what women really need.