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Septocaine Patient Information Including Side Effects

Brand Names: Septocaine

Generic Name: articaine and epinephrine (Pronunciation: AR ti kane and EP i NEF rin)

What is articaine and epinephrine (Septocaine)?

Articaine and epinephrine is an anesthetic (numbing medicine) that blocks the nerve impulses that send pain signals to your brain.

Articaine and epinephrine is used as an anesthetic for dental procedures.

Articaine and epinephrine may also be used for other purposes not listed in this medication guide.

What are the possible side effects of articaine and epinephrine (Septocaine)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling or puffiness of your face, lips, tongue, or throat.

Tell your caregivers at once if you have a serious side effect such as:

  • weak or shallow breathing;
  • slow heart rate, weak pulse;
  • feeling like you might pass out;
  • swelling in your face;
  • swollen or bleeding gums;
  • anxiety, confusion, restless feeling, tremors or shaking;
  • blurred vision, ringing in your ears; or
  • seizure (convulsions).

Less serious side effects may include:

  • tongue pain or swelling, mouth sores;
  • nausea, vomiting, constipation, diarrhea, upset stomach;
  • increased thirst, drooling;
  • nervousness, dizziness, drowsiness;
  • ear pain, neck pain, joint or muscle pain;
  • unusual or unpleasant taste in your mouth;
  • numbness or tingly feeling;
  • mild skin rash or itching; or
  • runny nose, sore throat.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Read the Septocaine (articane hcl and epinephrine injection) Side Effects Center for a complete guide to possible side effects

What is the most important information I should know about articaine and epinephrine (Septocaine)?

You should not receive articaine and epinephrine if you have ever had an allergic reaction to any type of numbing medicine.

Before receiving this medication, tell your dentist if you have high or low blood pressure, asthma or a sulfite allergy, or a history of seizures.

This medication can cause numbness for an extended period of time. Avoid eating, chewing gum, or drinking hot liquids until the feeling in your mouth has returned completely. Chewing while your mouth is numb could result in a bite injury to your tongue, lips, or inside of your cheek.

Side Effects Centers

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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