Serevent Diskus (Salmeterol Xinafoate) Drug Information: Overdosage and Contraindications

Pill Identifier Search

May 27, 2012

Serevent Diskus

Allergy »

Allergy facts

Allergy involves an exaggerated response of the immune system.
The immune system is the body's organized defense mechanism against foreign invaders, particularly infections.
Allergens are substances that are foreign to the body and can cause an allergic reaction.
IgE is the allergy antibody.
Allergies can develop at any age.
Your risk of developing allergies is related to your parents' allergy history.

Introduction

In this review you will learn how allergy relates to the immune system. You will begin understanding how and why certain people become allergic. The most common allergic diseases are discussed briefly in this article.

What does an allergy mean?

An allergy refers to an exaggerated reaction by our immune system in response to bodily contact with certain foreign substances. It is exaggerated because these f...

Read the Allergy article »

« Previous
1
2
3
4
5
6
7
8
9
10
11
12
13
Next »

Serevent Diskus User Reviews >>

Serevent Diskus

Asthma Slideshow Pictures

Take the Asthma Quiz!

10 Worst Cities for Asthma Slideshow Pictures

font size

OVERDOSE

The expected signs and symptoms with overdosage of SEREVENT DISKUS (salmeterol xinafoate) are those of excessive beta-adrenergic stimulation and/or occurrence or exaggeration of any of the following: seizures, angina, hypertension or hypotension, tachycardia with rates up to 200 beats/min, arrhythmias, nervousness, headache, tremor, muscle cramps, dry mouth, palpitation, nausea, dizziness, fatigue, malaise, insomnia. Overdosage with SEREVENT DISKUS (salmeterol xinafoate) can lead to clinically significant prolongation of the QTc interval, which can produce ventricular arrhythmias. Other signs of overdosage may include hypokalemia and hyperglycemia.

As with all sympathomimetic medications, cardiac arrest and even death may be associated with abuse of SEREVENT DISKUS (salmeterol xinafoate) .

Treatment consists of discontinuation of SEREVENT DISKUS (salmeterol xinafoate) together with appropriate symptomatic therapy. The judicious use of a cardioselective beta-receptor blocker may be considered, bearing in mind that such medication can produce bronchospasm. There is insufficient evidence to determine if dialysis is beneficial for overdosage of SEREVENT DISKUS (salmeterol xinafoate) . Cardiac monitoring is recommended in cases of overdosage.

No deaths were seen in rats given salmeterol at an inhalation dose of 2.9 mg/kg (approximately 240 and 110 times the MRHD for adults and children, respectively, on an mg/m² basis) and in dogs at an inhalation dose of 0.7 mg/kg (approximately 190 and 90 times the MRHD for adults and children, respectively, on an mg/m² basis). By the oral route, no deaths occurred in mice at 150 mg/kg (approximately 6,100 and 2,900 times the MRHD for adults and children, respectively, on an mg/m² basis) and in rats at 1,000 mg/kg (approximately 81,000 and 38,000 times the MRHD for adults and children, respectively, on an mg/m² basis).

CONTRAINDICATIONS

Because of the risk of asthma-related death and hospitalization, use of SEREVENT DISKUS (salmeterol xinafoate) for the treatment of asthma without concomitant use of a long-term asthma control medication, such as an inhaled corticosteroid, is contraindicated [see WARNINGS AND PRECAUTIONS.].

SEREVENT DISKUS (salmeterol xinafoate) is contraindicated as primary treatment of status asthmaticus or other acute episodes of asthma or COPD where intensive measures are required [see WARNINGS AND PRECAUTIONS.].

SEREVENT DISKUS (salmeterol xinafoate) is contraindicated in patients with severe hypersensitivity to milk proteins [see WARNINGS AND PRECAUTIONS, ADVERSE REACTIONS, DESCRIPTION].

Last reviewed on RxList: 2/28/2011
This monograph has been modified to include the generic and brand name in many instances.