March 28, 2017
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Sertraline

Brand Name: Zoloft

Generic Name: sertraline

Drug Class: Antidepressants, SSRIs

What Is Sertraline and How Does It Work?

Sertraline is a prescription medication indicated for the treatment of major depressive disorder (depression) in adults.

Sertraline is available under the following different brand names: Zoloft

Dosages of Sertraline Should Be Given As Follows:

Dosage Forms & Strengths

Tablets

  • 25mg
  • 50mg
  • 100mg

Oral concentrate

  • 20mg/mL

Dosage Considerations – Should be Given as Follows:

Major Depressive Disorder

  • Initial: 50 mg orally once/day
  • May increase by 25 mg at 1-week intervals; not to exceed 200 mg once/day
  • Geriatric: 25 mg orally once/day initially; may increase by 25 mg every 2-3 days; not to exceed 200 mg once/day
  • Alzheimer dementia related depression: Start at 12.5 mg/day and titrate every 1-2 weeks to response; not to exceed 150-200 mg

Obsessive-Compulsive Disorder

  • Initial: 50 mg orally once/day
  • May increase by 25 mg at 1-week intervals; not to exceed 200 mg once/day
  • Less than 6 years: Safety and efficacy not established
  • 6-12 years: 25 mg orally once/day initially
  • 12-17 years: 50 mg orally once/day initially; May increase by 50 mg once/day at 1-week intervals to no more than 200 mg once/day give once at bedtime if somnolence experienced

Panic Disorder, Posttraumatic Stress Disorder

  • Initial: 25 mg orally once/day

Premenstrual Syndrome (Off-label)

  • 0.25 mg orally once every 6-12 hours; initiate treatment on day 16-18 of menses (not to exceed 3-4 mg/day); taper dose over 2-3 days once menses occurs
  • May increase by 25 mg at 1-week intervals; not to exceed 200 mg once/day

Social Anxiety Disorder

  • Initial: 25 mg orally once/day
  • May increase by 25 mg at 1-week intervals not to exceed 200 mg once/day

Premenstrual Dysphoric Disorder

  • Initial: 50 mg orally once/day given continuously throughout menstrual cycle or given during luteal phase only
  • May increase by 50 mg at the onset of each new menstrual cycle; no more than 150 mg once/day when administered continuously or 100 mg once/day when administered during luteal phase only

Pruritus (Itching) (Off-label)

  • 25-100 mg daily for up to 5 years; 75-100 mg doses found to be most effective

Dosing Modifications

Renal impairment: Dose adjustment not necessary

Hepatic impairment

  • Mild (Child-Pugh 5-6): Decrease recommended starting dose and therapeutic dose by 50%
  • Moderate-to-severe (Child-Pugh 7-15): Not recommended; sertraline is extensively metabolized, and the effects in patients with moderate and severe hepatic impairment have not been studied

The elderly are prone to SSRI/SNRI-induced hyponatremia; monitor closely

Medically Reviewed by a Doctor on 3/9/2017



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