"There is no difference in response or remission rates produced by second-generation antidepressants and those achieved by cognitive-behavioral therapies (CBT) in the treatment of major depressive disorder (MDD), a systematic review and meta-analy"...
(Generic versions may still be available.)
Serzone Consumer (continued)
Some products that may interact with this drug include: carbamazepine, eplerenone, ergot alkaloids (such as dihydroergotamine, ergonovine, ergotamine, methylergonovine), ivabradine, lurasidone, pimozide, triazolam, alpha blockers (e.g., terazosin), digoxin, fluoxetine, medications for high blood pressure, other antidepressants (e.g., trazodone, SSRIs such as fluoxetine), other drugs that can cause bleeding/bruising (e.g., anticoagulants such as heparin or warfarin, antiplatelet drugs including NSAIDs such as ibuprofen).
Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before and 1 week after treatment with this medication. Ask your doctor when to start or stop taking this medication.
Avoid taking eletriptan within 72 hours of taking this medication.
This medication can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include buspirone, cyclosporine, dasatinib, domperidone, fentanyl, regorafenib, sunitinib, tacrolimus, "statin" cholesterol drugs (such as simvastatin, lovastatin, atorvastatin), certain benzodiazepines (such as alprazolam, diazepam) among others.
Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), anti-seizure drugs (e.g., phenytoin), medicine for sleep (e.g., zolpidem), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., chlorpromazine, risperidone, haloperidol).
Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-causing ingredients. Ask your pharmacist about using those products safely.
Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (NSAIDs such as aspirin, ibuprofen, naproxen) that may increase your risk for bleeding if taken together with this drug. Low-dose aspirin should be continued if prescribed by your doctor for specific medical reasons such as heart attack or stroke prevention (usually at dosages of 81-325 milligrams per day). Consult your doctor or pharmacist for more details.
Also report the use of drugs which might increase seizure risk when combined with nefazodone such as isoniazid (INH), phenothiazines (e.g., thioridazine), theophylline, or tricyclic antidepressants (e.g., amitriptyline), among others. Consult your doctor or pharmacist for details.
OVERDOSE: If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: nausea, vomiting, extreme drowsiness.
NOTES: Do not share this medication with others.
Psychiatric/medical checkups (and laboratory tests such as liver function tests) must be done periodically to monitor your progress and check for side effects. Consult your doctor for more details.
MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
STORAGE: Store at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
Information last revised March 2015. Copyright(c) 2015 First Databank, Inc.
Additional Serzone Information
- Serzone Drug Interactions Center: nefazodone oral
- Serzone Side Effects Center
- Serzone Overview including Precautions
- Serzone FDA Approved Prescribing Information including Dosage
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