Silvadene
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Silvadene
CLINICAL PHARMACOLOGY
Silver sulfadiazine has broad antimicrobial activity. It is bactericidal for many gram-negative and gram-positive bacteria as well as being effective against yeast. Results from in vitro testing are listed below.
Sufficient data have been obtained to demonstrate that silver sulfadiazine will inhibit bacteria that are resistant to other antimicrobial agents and that the compound is superior to sulfadiazine.
Studies utilizing radioactive micronized silver sulfadiazine, electron microscopy, and biochemical techniques have revealed that the mechanism of action of silver sulfadiazine on bacteria differs from silver nitrate and sodium sulfadiazine. Silver sulfadiazine acts only on the cell membrane and cell wall to produce its bactericidal effect.
Results of In Vitro Testing with SILVADENE® Cream
1% (silver sulfadiazine) Concentration of Silver Sulfadiazine Number of
Sensitive Strains/Total Number of Strains Tested
| Genus & Species | 50 μg/mL | 100 μg/mL |
| Pseudomonas aeruginosa | 130/130 | 130/130 |
| Xanthomonas (Pseudomonas) maltophilia | 7/7 | 7/7 |
| Enterobacter species | 48/50 | 50/50 |
| Enterobacter cloacae | 24/24 | 24/24 |
| Klebsiella species | 53/54 | 54/54 |
| Escherichia coli | 63/63 | 63/63 |
| Serratia species | 27/28 | 28/28 |
| Proteus mirabilis | 53/53 | 53/53 |
| Morganella morganii | 10/10 | 10/10 |
| Providencia rettgeri | 2/2 | 2/2 |
| Providencia species | 1/1 | 1/1 |
| Proteus vulgaris | 2/2 | 2/2 |
| Citrobacter species | 10/10 | 10/10 |
| Acinetobacter calcoaceticus | 10/11 | 11/11 |
| Staphylococcus aureus | 100/101 | 100/101 |
| Staphylococcus epidermidis | 51/51 | 51/51 |
| β-Hemolytic Streptococcus | 4/4 | 4/4 |
| Enterococcus species | 52/53 | 53/53 |
| Corynebacteriumdiphtheriae | 2/2 | 2/2 |
| Clostridium perfringens | 0/2 | 2/2 |
| Candida albicans | 43/50 | 50/50 |
Silver sulfadiazine is not a carbonic anhydrase inhibitor and may be useful in situations where such agents are contraindicated.
Last reviewed on RxList: 3/28/2013
This monograph has been modified to include the generic and brand name in many instances.
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