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Sinemet

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Sinemet

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Sinemet Drug Center

Medical Editor: John P. Cunha, DO, FACOEP

Sinemet (carbidopa-levodopa) is used to treat Parkinson symptoms such as muscle stiffness, tremors, spasms, and poor muscle control. This medication is also used to treat Parkinson symptoms caused by carbon monoxide poisoning or manganese intoxication. Carbidopa is an inhibitor of aromatic amino acid decarboxylation and levodopa is an aromatic amino acid. This medication is available in generic form. Common side effects include dizziness, nausea, vomiting, trouble sleeping, and headache.

Starting dosage is one tablet of Sinemet 25-100 (carbidopa-levodopa) three times a day. Dosage may be increased by one tablet every day or every other day, as necessary, until a dosage of eight tablets a day is reached. Sinemet may interact with other Parkinson's medications, metoclopramide, isoniazid, phenytoin, papaverine, blood pressure medication, antidepressants, or medicines to treat psychiatric disorders. Tell your doctor all medications you use. Sinemet should be used only when prescribed during pregnancy. Levodopa may pass into breast milk and affect milk production. Consult your doctor before breast-feeding.

Our Sinemet (carbidopa-levodopa) Drug Center provides a comprehensive view of available drug information as well as related drugs, user reviews, supplements, and diseases and conditions articles.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Sinemet Prescribing Information: Indications & Dosage

Carbidopa Structural Formula Illustration

SINEMET (carbidopa-levodopa) is indicated in the treatment of the symptoms of idiopathic Parkinson's disease (paralysis agitans), post-encephalitic parkinsonism, and symptomatic parkinsonism which may follow injury to the nervous system by carbon monoxide intoxication and/or manganese intoxication. SINEMET (carbidopa-levodopa) is indicated in these conditions to permit the administration of lower doses of levodopa with reduced nausea and vomiting, with more rapid dosage titration, with a somewhat smoother response, and with supplemental pyridoxine (vitamin B6...

Read the complete drug monograph for Sinemet »

What is Patient information?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Sinemet Patient Information: Side Effects

You may notice that your sweat, urine, or saliva appears dark in color, such as red, brown, or black. This is not a harmful side effect, but it may cause staining of your clothes or bed sheets.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • restless muscle movements in your eyes, tongue, jaw, or neck;
  • worsening of tremors (uncontrolled shaking);
  • high f...

Read the complete patient information for Sinemet »

What is Consumer information?

A concise overview of the drug for the patient or caregiver from First DataBank.

Sinemet Consumer Information: Uses

Levodopa and carbidopa are used in combination to treat the symptoms of Parkinson's disease or Parkinson-like symptoms (e.g., shakiness, stiffness, difficulty moving). Parkinson's disease is thought to be caused by too little of a naturally occurring substance (dopamine) in the brain. Levodopa changes into dopamine in the brain, helping to control movement.

Carbidopa prevents the breakdown of levodopa in the bloodstream so more levodopa can enter the brain. This can reduce some of levodopa's side effects such as nausea and vomiting, and it may also allow your doctor to increase your levodop...

Read the complete consumer information for Sinemet »

What is Sinemet Consumer Information?

Warnings - Uses - How to Use - Side Effects - Precautions - Drug Interactions and More

Sinemet - User Reviews

Sinemet User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Sinemet sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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