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SINEMET® (carbidopa-levodopa) is a combination of carbidopa and levodopa for the treatment of Parkinson's disease and syndrome.
Carbidopa, an inhibitor of aromatic amino acid decarboxylation, is a white, crystalline compound, slightly soluble in water, with a molecular weight of 244.3. It is designated chemically as (—)-L-α-hydrazino-α-methyl-β-(3,4-dihydroxybenzene) propanoic acid monohydrate. Its empirical formula is C10H14N2O4•H2O, and its structural formula is:
Tablet content is expressed in terms of anhydrous carbidopa which has a molecular weight of 226.3.
Levodopa, an aromatic amino acid, is a white, crystalline compound, slightly soluble in water, with a molecular weight of 197.2. It is designated chemically as (—)-L-α-amino-β-(3,4-dihydroxybenzene) propanoic acid. Its empirical formula is C9H11NO4, and its structural formula is:
SINEMET (carbidopa-levodopa) is supplied as tablets in three strengths:
SINEMET (carbidopa-levodopa) 25-100, containing 25 mg of carbidopa and 100 mg of levodopa.
SINEMET (carbidopa-levodopa) 10-100, containing 10 mg of carbidopa and 100 mg of levodopa.
SINEMET (carbidopa-levodopa) 25-250, containing 25 mg of carbidopa and 250 mg of levodopa.
Inactive ingredients are hydroxypropyl cellulose, pregelatinized starch, crospovidone, microcrystalline cellulose, and magnesium stearate. SINEMET (carbidopa-levodopa) 10-100 and 25-250 Tablets also contain FD&C Blue #2/lndigo Carmine AL. SINEMET (carbidopa-levodopa) 25-100 Tablets also contain D&C Yellow #10 Lake.
What are the possible side effects of carbidopa and levodopa (Atamet, Parcopa, Sinemet, Sinemet CR)?
You may notice that your sweat, urine, or saliva appears dark in color, such as red, brown, or black. This is not a harmful side effect, but it may cause staining of your clothes or bed sheets.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- restless muscle movements in your eyes, tongue, jaw, or neck;
- worsening of tremors...
What are the precautions when taking carbidopa-levodopa (Sinemet)?
Before taking this medication, tell your doctor or pharmacist if you are allergic to carbidopa or levodopa; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain eye problem (narrow-angle glaucoma).
Before using this medication, tell your doctor or pharmacist your medical history, especially of: bleeding disorders, breathing problems (e.g., asthma, emphysema), certain eye problem (wide-angle glaucoma), heart or blood vessel problems (e.g., arrhythmias, heart attack, angina), kidney disease,...
Last reviewed on RxList: 3/28/2011
This monograph has been modified to include the generic and brand name in many instances.
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