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Antidepressants are a class of drugs that reduce symptoms of depressive disorders by correcting chemical imbalances of neurotransmitters in the brain. Chemical imbalances may be responsible for changes in mood and behavior.
Neurotransmitters are vital, as they are the communication link between nerve cells in the brain. Neurotransmitters reside within vesicles found in nerve cells, which are released by one nerve and taken up by other nerves. Neurotransmitters not taken up by other nerves are taken up by the same nerves that released them. This process is called "reuptake." The prevalent neurotransmitters in the brain specific to depression are serotonin, dopamine and norepinephrine (also called noradrenaline).
In general, antidepressants work by inhibiting the reuptake of specific neurotransmitters, hence increasing their levels around the nerves within the brain, such...
Medical Editor: John P. Cunha, DO, FACOEP
Sinequan (doxepin) is used to treat symptoms of depression and/or anxiety associated with alcoholism, psychiatric conditions, or manic-depressive conditions. It is a tricyclic antidepressant. The brand name Sinequan is discontinued in the U.S. Generic forms are available. Common side effects include drowsiness, dizziness, dry mouth, blurred vision, constipation, or trouble urinating. Suicidal thinking and behavior may occur in children, adolescents, and young adults. Tell your doctor immediately if you have suicidal thoughts.
For most patients with illness of mild to moderate severity, a starting daily dose of 75 mg doxepin is recommended. The usual optimum dose range is 75 mg/day to 150 mg/day. Doxepin may interact with SSRI antidepressants, cimetidine, or heart rhythm medications. Tell your doctor all medications you use. During pregnancy, doxepin should be used only when prescribed. Since untreated depression can be a serious condition, do not stop using this medication unless directed by your doctor. This medication passes into breast milk and may have undesirable effects on a nursing infant. Breast-feeding while using this drug is not recommended.
Our Sinequan (doxepin) Drug Center provides a comprehensive view of available drug information as well as related drugs, user reviews, supplements, and diseases and conditions articles.
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
SINEQUAN (doxepin) is recommended for the treatment of:
Read the complete drug monograph for Sinequan »
Drug Description - Indications & Dosage - Side Effects & Drug Interactions - Warnings & Precautions - Contraindications - Medication Guide and More
What is Patient information?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have any of these serious side effects:
Read the complete patient information for Sinequan »
Possible Side Effects - Images - What Is - How Should I Take It - What If I Miss a Dose - What Should I Avoid and More
What is Consumer information?
A concise overview of the drug for the patient or caregiver from First DataBank.
HOW TO USE: Read the Medication Guide provided by your pharmacist before you start taking doxepin and each time you get a refill. If you have any quest...
Read the complete consumer information for Sinequan »
Warnings - Uses - How to Use - Side Effects - Precautions - Drug Interactions and More
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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