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Sinequan

Last reviewed on RxList: 1/17/2017
Sinequan Side Effects Center

Last reviewed on RxList 9/16/2016

Sinequan (doxepin) is a tricyclic antidepressant used to treat symptoms of depression and/or anxiety associated with alcoholism, psychiatric conditions, or manic-depressive conditions. The brand name Sinequan is discontinued in the U.S. Generic forms are available. Common side effects of Sinequan include:

  • drowsiness,
  • dizziness,
  • tiredness,
  • dry mouth,
  • blurred vision,
  • ringing in your ears,
  • nausea,
  • vomiting,
  • constipation,
  • weight gain,
  • increased sweating,
  • breast swelling (in men or women),
  • decreased sex drive, or
  • trouble urinating.

Suicidal thinking and behavior may occur in children, adolescents, and young adults taking Sinequan. Tell your doctor immediately if you have suicidal thoughts while taking Sinequan.

For most patients with illness of mild to moderate severity, a starting daily dose of 75 mg doxepin is recommended. The usual optimum dose range is 75 mg/day to 150 mg/day. Doxepin may interact with SSRI antidepressants, cimetidine, or heart rhythm medications. Tell your doctor all medications you use. During pregnancy, doxepin should be used only when prescribed. Since untreated depression can be a serious condition, do not stop using this medication unless directed by your doctor. This medication passes into breast milk and may have undesirable effects on a nursing infant. Breastfeeding while using this drug is not recommended.

Our Sinequan (doxepin) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Sinequan Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

  • fast heart rate;
  • skin rash, bruising, severe tingling, numbness, pain, muscle weakness;
  • feeling like you might pass out;
  • tremors, restless muscle movements in your eyes, tongue, jaw, or neck;
  • confusion, hallucinations, unusual thoughts, seizure (convulsions); or
  • painful or difficult urination, urinating less than usual.

Other common side effects may include:

  • feeling dizzy, drowsy, or tired;
  • nausea, vomiting, constipation;
  • dry mouth, blurred vision, ringing in your ears;
  • weight gain, increased sweating;
  • breast swelling (in men or women); or
  • decreased sex drive.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Sinequan (Doxepin)

Sinequan Professional Information

SIDE EFFECTS

NOTE: Some of the adverse reactions noted below have not been specifically reported with SINEQUAN use. However, due to the close pharmacological similarities among the tricyclics, the reactions should be considered when prescribing SINEQUAN (doxepin HCl).

Anticholinergic Effects

Dry mouth, blurred vision, constipation, and urinary retention have been reported. If they do not subside with continued therapy, or become severe, it may be necessary to reduce the dosage.

Central Nervous System Effects

Drowsiness is the most commonly noticed side effect. This tends to disappear as therapy is continued. Other infrequently reported CNS side effects are confusion, disorientation, hallucinations, numbness, paresthesias, ataxia, extrapyramidal symptoms, seizures, tardive dyskinesia, and tremor.

Cardiovascular

Cardiovascular effects including hypotension, hypertension, and tachycardia have been reported occasionally.

Allergic

Skin rash, edema, photosensitization, and pruritus have occasionally occurred.

Hematologic

Eosinophilia has been reported in a few patients. There have been occasional reports of bone marrow depression manifesting as agranulocytosis, leukopenia, thrombocytopenia, and purpura.

Gastrointestinal

Nausea, vomiting, indigestion, taste disturbances, diarrhea, anorexia, and aphthous stomatitis have been reported. (See Anticholinergic Effects.)

Endocrine

Raised or lowered libido, testicular swelling, gynecomastia in males, enlargement of breasts and galactorrhea in the female, raising or lowering of blood sugar levels, and syndrome of inappropriate antidiuretic hormone secretion have been reported with tricyclic administration.

Other

Dizziness, tinnitus, weight gain, sweating, chills, fatigue, weakness, flushing, jaundice, alopecia, headache, exacerbation of asthma, angle closure glaucoma, mydriasis and hyperpyrexia (in association with chlorpromazine) have been occasionally observed as adverse effects.

Withdrawal Symptoms

The possibility of development of withdrawal symptoms upon abrupt cessation of treatment after prolonged SINEQUAN administration should be borne in mind. These are not indicative of addiction and gradual withdrawal of medication should not cause these symptoms.

Read the entire FDA prescribing information for Sinequan (Doxepin)

Related Resources for Sinequan

Read the Sinequan User Reviews »

© Sinequan Patient Information is supplied by Cerner Multum, Inc. and Sinequan Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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