"May 4, 2011 -- The osteoporosis drugs known as bisphosphonates increase the risk of getting unusual thigh bone fractures, as experts have suspected, according to a new Swedish study.
But these fractures are infrequent and the risk is "...
SKELID (tiludronate) is a bisphosphonate characterized by a (4-chlorophenylthio) group on the carbon atom of the basic P-C-P structure common to all bisphosphonates. Its generic name is tiludronate disodium. Tiludronate disodium is the hydrated hemihydrate form of the disodium salt of tiludronic acid. Its chemical name is [[(4-Chlorophenyl) thio]methylene]bis[phosphonic acid], disodium salt, and its structural formula is as follows:
SKELID tablets for oral administration contain 240 mg tiludronate disodium, which is the molar equivalent of 200 mg tiludronic acid. SKELID (tiludronate) tablets also contain sodium lauryl sulfate, hydroxypropyl methylcellulose 2910, crospovidone, magnesium stearate, and lactose monohydrate.
What are the possible side effects of tiludronate (Skelid)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using tiludronate and call your doctor at once if you have any of these serious side effects:
- painful or difficult swallowing;
- severe heartburn, burning pain in your upper stomach, or coughing up blood;
- severe joint, bone, or muscle pain;
- jaw pain, numbness, or swelling;
- severe diarrhea;
- bone fracture; or
- a red, blistering, peeling skin rash.
What are the precautions when taking tiludronate (Skelid)?
Before taking tiludronate, tell your doctor or pharmacist if you are allergic to it; or to other bisphosphonates (such as alendronate, etidronate); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, inability to sit upright or stand for at least 30 minutes, difficult/painful swallowing, esophagus problems (such as heartburn, narrowing of the esophagus), stomach/intestinal problems (such as ulcers), low level of calcium in the blood.
Infrequently, people taking this class of medication (bisphosphonates) have had serious jawbone problems...
Last reviewed on RxList: 4/14/2010
This monograph has been modified to include the generic and brand name in many instances.
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