Skelid (Tiludronate) Drug Information: Medication Guide and Patient Information

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May 27, 2012

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Paget's Disease »

What is Paget's disease?

Paget's disease is a chronic condition of bone characterized by disorder of the normal bone remodeling process. Normal bone has a balance of forces that act to lay down new bone and take up old bone. This relationship (referred to as "bone remodeling") is essential for maintaining the normal calcium levels in our blood. In bone affected by Paget's disease, the bone remodeling is disturbed and not synchronized. As a result, the bone that is formed is abnormal, enlarged, not as dense, brittle, and prone to breakage (fracture).

Paget's disease affects older skeletal bone of adults. It's estimated that 1% of adults in the U.S. have Paget's disease. There is also an extremely rare form of Paget's disease in children, referred to as juvenile Paget's disease. Paget's disease is also known as osteitis deformans.

What causes Paget's disease?

It is not known what causes Paget's disease. Recently, certain...

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PATIENT INFORMATION

Patients receiving SKELID (tiludronate) should be instructed to:

Take SKELID (tiludronate) with 6 to 8 ounces of plain water.
Not lie down for at least 30 minutes after taking this medication.
SKELID (tiludronate) should not be taken within 2 hours of food.
Maintain adequate vitamin D and calcium intake.
Calcium supplements, aspirin, and indomethacin should not be taken within 2 hours before or 2 hours after SKELID (tiludronate) .
Aluminum- or magnesium-containing antacids, if needed, should be taken at least 2 hours after taking SKELID (tiludronate) .

Last reviewed on RxList: 4/14/2010
This monograph has been modified to include the generic and brand name in many instances.