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Paget's disease is a chronic condition of bone characterized by disorder of the normal bone remodeling process. Normal bone has a balance of forces that act to lay down new bone and take up old bone. This relationship (referred to as "bone remodeling") is essential for maintaining the normal calcium levels in our blood. In bone affected by Paget's disease, the bone remodeling is disturbed and not synchronized. As a result, the bone that is formed is abnormal, enlarged, not as dense, brittle, and prone to breakage (fracture).
Paget's disease affects older skeletal bone of adults. It's estimated that 1% of adults in the U.S. have Paget's disease. There is also an extremely rare form of Paget's disease in children, referred to as juvenile Paget's disease. Paget's disease is also known as osteitis deformans.
It is not known what causes Paget's disease. Recently, certain...
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Based on the known action of tiludronate, hypocalcemia is a potential consequence of SKELID (tiludronate) overdose. In one patient with hypercalcemia of malignancy, intravenous administration of high doses of SKELID (tiludronate) (800 mg/day total dose, 6 mg/kg/day for 2 days) was associated with acute renal failure and death.
No specific information is available on the treatment of overdose with SKELID (tiludronate) . Dialysis would not be beneficial. Standard medical practices may be used to manage renal insufficiency or hypocalcemia, if signs of these develop.
SKELID (tiludronate) is contraindicated in individuals with known hypersensitivity to any component of this product.
Inability to stand or sit upright for at least 30 minutes.
Last reviewed on RxList: 4/14/2010
This monograph has been modified to include the generic and brand name in many instances.
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