Skelid (Tiludronate) Patient Information: How Should I Take the Drug at RxList

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May 27, 2012

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Paget's Disease »

What is Paget's disease?

Paget's disease is a chronic condition of bone characterized by disorder of the normal bone remodeling process. Normal bone has a balance of forces that act to lay down new bone and take up old bone. This relationship (referred to as "bone remodeling") is essential for maintaining the normal calcium levels in our blood. In bone affected by Paget's disease, the bone remodeling is disturbed and not synchronized. As a result, the bone that is formed is abnormal, enlarged, not as dense, brittle, and prone to breakage (fracture).

Paget's disease affects older skeletal bone of adults. It's estimated that 1% of adults in the U.S. have Paget's disease. There is also an extremely rare form of Paget's disease in children, referred to as juvenile Paget's disease. Paget's disease is also known as osteitis deformans.

What causes Paget's disease?

It is not known what causes Paget's disease. Recently, certain...

Read the Paget's Disease article »

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Skelid Patient Information including How Should I Take

What should I discuss with my healthcare provider before taking tiludronate (Skelid)?

Do not take this medication if you are allergic to tiludronate.

Before using tiludronate, tell your doctor if you have:

low blood calcium (hypocalcemia);
a vitamin D deficiency;
kidney disease; or
an ulcer in your stomach or esophagus.

If you have any of these conditions, you may not be able to use tiludronate, or you may need a dosage adjustment or special tests during treatment.

Some people using medicines similar to tiludronate have developed bone loss in the jaw, also called osteonecrosis of the jaw. Symptoms of this condition may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums.

You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. Other conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia (low red blood cells), and dental surgery or pre-existing dental problems.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether tiludronate passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take tiludronate (Skelid)?

Take tiludronate exactly as it was prescribed for you. Do not use the medication in larger amounts or for longer than recommended by your doctor.

Tiludronate tablets are usually taken once each day for at least 3 months.

Take tiludronate on an empty stomach, at least 2 hours before or 2 hours after eating.

Your doctor may ask you to take the medicine first thing in the morning, before you eat or drink anything or take any other medicine.

Take each dose with a full glass (6 to 8 ounces) of water. Use only plain water (not mineral water) when taking a tiludronate tablet.

Wait at least 2 hours after taking tiludronate before you eat or take other medicines including vitamins, calcium, or antacids. Do not take tiludronate if it has been less than 2 hours since your last meal or other medication.

Do not crush, chew, or suck the tiludronate tablet. Swallow the pill whole.

Your doctor may want you to take calium or vitamin D supplements while you are taking tiludronate. Follow your medication and dose schedules very closely.

Store tiludronate tablets at room temperature away from moisture and heat.

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