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The committee voted 12-9 against continued marketing of the drug, citing"...
Skelid Patient Information Including Side Effects
Brand Names: Skelid
Generic Name: tiludronate (Pronunciation: til UD ro nayt)
- What is tiludronate (Skelid)?
- What are the possible side effects of tiludronate (Skelid)?
- What is the most important information I should know about tiludronate (Skelid)?
- What should I discuss with my healthcare provider before taking tiludronate (Skelid)?
- How should I take tiludronate (Skelid)?
- What happens if I miss a dose (Skelid)?
- What happens if I overdose (Skelid)?
- What should I avoid while taking tiludronate (Skelid)?
- What other drugs will affect tiludronate (Skelid)?
- Where can I get more information?
What is tiludronate (Skelid)?
Tiludronate is in the group of medicines called bisphosphonates (bis FOS fo nayts). It alters the cycle of bone formation and breakdown in the body.
Tiludronate is used to treat Paget's disease of bone.
Tiludronate may also be used for purposes not listed in this medication guide.
What are the possible side effects of tiludronate (Skelid)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using tiludronate and call your doctor at once if you have any of these serious side effects:
- painful or difficult swallowing;
- severe heartburn, burning pain in your upper stomach, or coughing up blood;
- severe joint, bone, or muscle pain;
- jaw pain, numbness, or swelling;
- severe diarrhea;
- bone fracture; or
- a red, blistering, peeling skin rash.
Less serious side effects may include:
- nausea, vomiting, upset stomach;
- mild diarrhea; or
- runny or stuffy nose.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Read the Skelid (tiludronate) Side Effects Center for a complete guide to possible side effects »
What is the most important information I should know about tiludronate (Skelid)?
Take tiludronate with a full glass (6 to 8 ounces) of water. Use only plain water (not mineral water) when taking a tiludronate tablet.
For at least the first 2 hours after taking tiludronate, do not eat or drink anything other than plain water, and do not take any other medicines including vitamins or mineral supplements.
Especially avoid drinking milk or eating dairy products within 2 hours after taking tiludronate. Also avoid taking supplements that contain calcium, magnesium, iron, or aluminum (such as in multivitamins with iron, and in many types of antacids).
Some people using medicines similar to tiludronate have developed bone loss in the jaw, also called osteonecrosis of the jaw. Symptoms may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums. You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. Other conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia (low red blood cells), and a pre-existing dental problem.
If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are using tiludronate. You may need to stop using the medicine for a short time.
Talk with your doctor about the risks and benefits of using this medication.
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