"May 4, 2011 -- The osteoporosis drugs known as bisphosphonates increase the risk of getting unusual thigh bone fractures, as experts have suspected, according to a new Swedish study.
But these fractures are infrequent and the risk is "...
Skelid Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Skelid (tiludronate disodium) is a bisphosphonate used to treat Paget's disease of bone. The brand name of this medication is discontinued, but generic versions may be available. Common side effects include nausea or diarrhea.
A single 400-mg daily oral dose of Skelid, taken with 6 to 8 ounces of plain water only, should be administered for a period of 3 months. Skelid may interact with other drugs. Tell your doctor all medications and supplements you use. Caution is advised if you are pregnant or planning to become pregnant in the future. Skelid may stay in your body for many years. Its effects on a fetus are unknown. Consult your doctor before starting treatment with Skelid. It is unknown if this drug passes into breast milk, and the effect on a nursing infant is unknown. Consult your doctor before breastfeeding.
Our Skelid (tiludronate disodium) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Skelid in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using tiludronate and call your doctor at once if you have any of these serious side effects:
- painful or difficult swallowing;
- severe heartburn, burning pain in your upper stomach, or coughing up blood;
- severe joint, bone, or muscle pain;
- jaw pain, numbness, or swelling;
- severe diarrhea;
- bone fracture; or
- a red, blistering, peeling skin rash.
Less serious side effects may include:
- nausea, vomiting, upset stomach;
- mild diarrhea; or
- runny or stuffy nose.
Read the entire detailed patient monograph for Skelid (Tiludronate)
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Skelid Overview - Patient Information: Side Effects
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Skelid (Tiludronate)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Skelid FDA Prescribing Information: Side Effects
The safety of SKELID (tiludronate) has been studied in more than 1100 patients, and the adverse experience profile is similar between controlled and uncontrolled clinical trials. Adverse events occurring in placebo-controlled trials of pagetic patients treated with SKELID (tiludronate) 400 mg/day are presented in the table below.
Adverse events associated with SKELID (tiludronate) usually have been mild, and generally have not required discontinuation of therapy. In two placebo-controlled trials, 1.3% of patients receiving 400 mg SKELID (tiludronate) and 5.4% of patients receiving placebo discontinued therapy due to any clinical adverse event.
Adverse Eventsa (%) Reportedb in >
2% of Pagetic Patients from Placebo-Controlled Studies
| SKELID (tiludronate)
|BODY AS A WHOLE|
|Central and Peripheral Nervous Systems|
|Metabolic and Nutritional|
|Vitamin D Deficiency||2.7||2.7|
|Upper Respiratory Tract Infection||5.3||14.9|
|Skin and Appendage|
a Reported using WHO terminology
b All events reported, irrespective of causality
Other adverse events not listed in the table above but reported in ≥ 1% of pagetic patients treated with SKELID (tiludronate) in all clinical trials of at least one month duration, regardless of dose and causality assessment, are listed below. The adverse event terms within each body system are listed in the order of decreasing frequency occurring in the population.
Central and Peripheral Nervous Systems: Vertigo, involuntary muscle contractions
Musculoskeletal: Fracture pathological
Respiratory System: Bronchitis
Skin and Appendages: Pruritus, increased sweating
Urinary System: Urinary tract infection
Vascular (extracardiac): Flushing
Stevens-Johnson type syndrome has been observed rarely; the causality relationship of this to SKELID (tiludronate) has not been established.
Read the entire FDA prescribing information for Skelid (Tiludronate)
Additional Skelid Information
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