May 26, 2017
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"The US Food and Drug Administration (FDA) today approved a drug for children and adults with hemophilia B called albutrepenonacog alfa (Idelvion, CSL Behring), which combines albumin with factor IX to reduce injection frequency.



Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Side Effects


The following adverse reactions have been observed, but there has not been enough systematic collection of data to support an estimate of their frequency. The most consistent adverse reactions are usually due to overdosage.

Gastrointestinal: nausea, vomiting, epigastric pain, hematemesis, diarrhea.

Central Nervous System: headaches, irritability, restlessness, insomnia, reflex hyperexcitability, muscle twitching, clonic and tonic generalized convulsions.

Cardiovascular: palpitation, tachycardia, extrasystoles, flushing, hypotension, circulatory failure, ventricular arrhythmias.

Respiratory: tachypnea.

Renal: potentiation of diuresis.

Other: alopecia, hyperglycemia, inappropriate ADH syndrome, rash.

Read the Slo-phyllin (theophylline, anhydrous) Side Effects Center for a complete guide to possible side effects


Drug-Drug Interactions: Toxic synergism with ephedrine has been documented and may occur with some other sympathomimetic bronchodilators. In addition, the following drug interactions have been demonstrated:

Theophylline with Drug Effect
Allopurinol (high dose) Increased serum theophylline levels
Cimetidine Increased serum theophylline levels
Ciprofloxacin  Increased serum theophylline levels
Erythromycin, Troleandomycin Increased serum theophylline levels
Lithium carbonate  Increased renal excretion of lithium
Oral contraceptives Increased serum theophylline levels
Propranolol Increased serum theophylline levels
Phenytoin Decreased theophylline and phenytoin serum levels
Rifampin Decreased serum theophylline levels

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 12/8/2004

Side Effects

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