"The US Food and Drug Administration (FDA) today approved asfotase alfa (Strensiq, Alexion Pharmaceuticals) as the first-ever therapy for patients who develop hypophosphatasia, a rare metabolic bone disorder, in childhood.
(Generic versions may still be available.)
The following adverse reactions have been observed, but there has not been enough systematic collection of data to support an estimate of their frequency. The most consistent adverse reactions are usually due to overdosage.
Read the Slo-phyllin (theophylline, anhydrous) Side Effects Center for a complete guide to possible side effects
Drug-Drug Interactions: Toxic synergism with ephedrine has been documented and may occur with some other sympathomimetic bronchodilators. In addition, the following drug interactions have been demonstrated:
|Theophylline with Drug||Effect|
|Allopurinol (high dose)||Increased serum theophylline levels|
|Cimetidine||Increased serum theophylline levels|
|Ciprofloxacin||Increased serum theophylline levels|
|Erythromycin, Troleandomycin||Increased serum theophylline levels|
|Lithium carbonate||Increased renal excretion of lithium|
|Oral contraceptives||Increased serum theophylline levels|
|Propranolol||Increased serum theophylline levels|
|Phenytoin||Decreased theophylline and phenytoin serum levels|
|Rifampin||Decreased serum theophylline levels|
This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 12/8/2004
Additional Slo-phyllin Information
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