Sodium Acetate (sodium acetate (sodium acetate (sodium acetate injection) injection) injection) Injection, USP 40 mEq (2 mEq/mL) is a sterile, nonpyrogenic, concentrated solution of sodium acetate (sodium acetate (sodium acetate (sodium acetate injection) injection) injection) in water for injection. The solution is administered, after dilution, by the intravenous route as an electrolyte replenisher. It must not be administered undiluted. Each 20 mL contains 3.28 g of sodium acetate (sodium acetate (sodium acetate (sodium acetate injection) injection) injection) (anhydrous) which provides 40 mEq each of sodium (Na⁺) and acetate (CH₃COO^-). The solution contains no bacteriostat, antimicrobial agent or added buffer. May contain acetic acid for pH adjustment; the pH is 6.5 (6.0 to 7.0). The osmolar concentration is 4 mOsmol/mL (calc).

The solution is intended as an alternative to sodium chloride to provide sodium ion (Na⁺) for addition to large volume infusion fluids for intravenous use.

Sodium Acetate (sodium acetate (sodium acetate (sodium acetate injection) injection) injection) , USP (anhydrous) is chemically designated CH₃COONa, a hygroscopic powder very soluble in water. The semi-rigid container is fabricated from a specially formulated polyolefin. It is a copolymer of ethylene and propylene. The safety of the plastic has been confirmed by tests in animals according to USP biological standards for plastic containers. The container requires no vapor barrier to maintain the proper drug concentration.

Last reviewed on RxList: 5/19/2009
This monograph has been modified to include the generic and brand name in many instances.