July 23, 2016
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Sodium Bicarbonate

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Sodium Bicarbonate

Sodium Bicarbonate Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Sodium Bicarbonate (sodium bicarbonate 5% injection) is used to treat metabolic acidosis which can occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock, anoxia or severe dehydration, extracorporeal circulation of blood and severe primary lactic acidosis. It is also used to treat certain drug intoxications, including barbiturates, or salicylates or methyl alcohol poisoning. It is an electrolyte alkalinizer. This medication is available in generic form. Common side effects include fever, infection at the site of injection, phlebitis, or hypervolemia.

Dosage of Sodium Bicarbonate depends on the condition being treated and the weight of the patient. Sodium Bicarbonate may interact with other drugs. Tell your doctor all prescription and over-the-counter medications and supplements you use. During pregnancy, Sodium Bicarbonate should only be used if prescribed. Consult your doctor before breast-feeding.

Our Sodium Bicarbonate (sodium bicarbonate 5% injection) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Sodium Bicarbonate FDA Prescribing Information: Side Effects
(Adverse Reactions)


Overdose of sodium bicarbonate (sodium bicarbonate 5% injection) may result in a severe degree of alkalosis which may be accompanied by hyperirritability or tetany. Should alkalosis result, the bicarbonate should be stopped and the patient managed according to the degree of alkalosis present. Severe alkalosis may be controlled by parenteral injections of calcium gluconate or an acidifying agent such as ammonium chloride.

Reactions which may occur because of the solution or the technique of administration include febrile response, infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection, extravasation, and hypervolemia.

If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate therapeutic countermeasures and save the remainder of the fluid for examination if deemed necessary.

Read the entire FDA prescribing information for Sodium Bicarbonate (Sodium Bicarbonate 5% Injection)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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