Sodium Iodide I 131
"The U.S. Food and Drug Administration today approved Cometriq (cabozantinib) to treat medullary thyroid cancer that has spread to other parts of the body (metastasized).
Medullary thyroid cancer develops in cells in the thyroid gland that m"...
Sodium Iodide I 131
SODIUM IODIDE I 131
(sodium iodide, i-131) Capsule
Sodium Iodide 131 (Na 131I) for diagnostic use is supplied for oral administration in opaque white gelatin capsules. The capsules are available in a strength of 3.7 megabecquerels (100 microcuries) iodine I-131 at the time of calibration.
Sodium Iodide I 131 (sodium iodide i 131 (sodium iodide i 131 capsules) capsules) Capsules are prepared by absorbing a solution of carrier-free sodium iodide I-131 into inert fillers. The iodine I-131 utilized in the preparation of the capsules contains not less than 99% iodine I-131 at the time of calibration.
Iodine I-131 decays by beta and associated gamma emissions with a physical half-life of 8.04 days.1 The principle beta emissions and gamma photons are listed in Table 1.
Table 1. Principal Radiation Emission Data
|Radiation||Mean Percent Per
The specific gamma ray constant for iodine I-131 is 2.27 R/hr-mCi at 1 cm. The first half-value thickness of lead (Pb) for iodine I-131 is 0.24 cm. A range of values for the relative attenuation of the radiation emitted by this radionuclide that results from interposition of various thicknesses of Pb is shown in Table 2. For example, the use of 4.6 cm of Pb will decrease the external radiation exposure by a factor of about 1,000.
Table 2. Radiation Attenuation by Lead Shielding*
|Shield Thickness (Pb), cm||Coefficient of Attenuation|
|*Data supplied by Oak Ridge Associated Universities, Radiopharmaceutical Internal Dose Information Center, Oak Ridge, TN, 1987.|
To correct for physical decay of this radionuclide, the fractions that remain at selected time intervals after the date of calibration are shown in Table 3.
Table 3. Physical Decay Chart, Iodine I-131, Half Life 8.04 Days
|Days||Fraction Remaining||Days||Fraction Remaining|
1Kocher, David C., “Radioactive Decay Data Tables,” DOE/TIC 11026, page 133 (1981).
Last reviewed on RxList: 5/19/2009
This monograph has been modified to include the generic and brand name in many instances.
Additional Sodium Iodide I 131 Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Find out what women really need.