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home > drugs a-z list > sodium sulfacetamide 10% and sulfur 5% lotion (sulfacetamide and sulfur) drug center > sodium sulfacetamide 10% and sulfur 5% lotion (sulfacetamide and sulfur) drug - clinical pharmacology
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Sodium Sulfacetamide and Sulfur Lotion
What is acne?
Acne (acne vulgaris, common acne) is a disease of the hair follicles of the face, chest, and back that affects almost all males and females during puberty; the only exception being teenage members of a few primitive isolated tribes living in Neolithic societies. It is not caused by bacteria, although bacteria play a role in its development. It is not unusual for some women to develop acne in their mid- to late-20s.
Acne appears on the skin as...
- congested pores ("comedones"), also known as blackheads or whiteheads,
- tender red bumps also known as pimples or zits,
- pustules, and occasionally as
- cysts (deep pimples, boils).
You can do a lot to treat your acne using products available at a drugstore or cosmetic counter that do not require a prescription. However, for tougher cases of acne, you should consult a physician for treatment options.
What...
Sodium Sulfacetamide 10% and Sulfur 5% lotion
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CLINICAL PHARMACOLOGY
The most widely accepted mechanism of action of sulfonamides is the Woods-Fildes theory which is based on the fact that sulfonamides act as competitive antagonists to para-aminobenzoic acid (PABA), an essential component for bacterial growth. While absorption through intact skin has not been determined, sodium sulfacetamide is readily absorbed from the gastrointestinal tract when taken orally and excreted in the urine, largely unchanged. The biological half-life has variously been reported as 7 to 12.8 hours.
The exact mode of action of sulfur in the treatment of acne is unknown, but it has been reported that it inhibits the growth of Propionibacterium acnes and the formation of free fatty acids.
Last reviewed on RxList: 1/29/2009
This monograph has been modified to include the generic and brand name in many instances.
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