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(mequinol, tretinoin) Topical Solution

For Topical use only.


Solagé contains mequinol 2% and tretinoin 0.01%, by weight, in a solution base of ethyl alcohol (77.8% v/v), polyethylene glycol 400, butylated hydroxytoluene, ascorbic acid, citric acid, ascorbyl palmitate, edetate disodium, and purified water.

Mequinol is 4-hydroxyanisole, the monomethyl ether of hydroquinone or 1-hydroxy-4-methoxybenzene. It has the chemical formula, C7H8O2, a molecular weight of 124.14, and the structural formula:

Mequinol Structural Formula Illustration

The chemical name for tretinoin, a retinoid, is (all-E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid, also referred to as all-trans-retinoic acid. It has the chemical formula, C20H28O2, a molecular weight of 300.44, and the structural formula:

Tretinoin Structural Formula Illustration

What are the possible side effects of mequinol and tretinoin topical (Solage)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Mequinol and tretinoin can cause some stinging, burning, warmth, tingling, itching, redness, swelling, dryness, peeling, or other skin irritation. Stop using the medication and call your doctor if any of these side effects become severe. You may need to use less of the medication or apply it less often.

This is not a complete list of side effects and others may occur. Tell your doctor about any...

Read All Potential Side Effects and See Pictures of Solage »

What are the precautions when taking mequinol and tretinoin (Solage)?

Before using this medication, tell your doctor or pharmacist if you are allergic to it; or to vitamin A-related drugs (other retinoids such as isotretinoin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: vitiligo, eczema.

This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths or sunlamps. Wear protective clothing when outdoors. Other medications (e.g., antibiotics such as ciprofloxacin, sulfamethoxazole, tetracycline) may increase your sun sensitivity. Ask your doctor or pharmacist for more...

Read All Potential Precautions of Solage »

Last reviewed on RxList: 12/29/2016
This monograph has been modified to include the generic and brand name in many instances.

Solage - User Reviews

Solage User Reviews

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Here is a collection of user reviews for the medication Solage sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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