Solodyn

Solodyn

Solodyn Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Solodyn (minocycline hydrochloride) is used to treat many different bacterial infections, such as urinary tract infections, severe acne, gonorrhea, tick fever, chlamydia, and others. It is a tetracycline antibiotic. This medication is available in generic form. Common side effects include nausea, vomiting, diarrhea, lightheadedness, dizziness, unsteadiness, drowsiness, mild headache, mouth sores, or cough.

The recommended dosage of Solodyn is approximately 1 mg/kg once daily for 12 weeks. Solodyn may interact with cholesterol-lowering medications, isotretinoin, tretinoin, antacids, products containing bismuth subsalicylate (e.g. Pepto-Bismol), minerals such as iron, zinc, calcium, magnesium, and over-the-counter vitamin and mineral supplements, blood thinners, or penicillin antibiotics. Tell your doctor all medications or supplements you are taking. Solodyn is not recommended for use during pregnancy because of possible harm to a fetus. It should not be used in women or men trying to have a child. Women of child-bearing age and men should use birth control while taking this medication. This medication passes into breast milk in very small amounts. While there have been no reports of harm to nursing infants, consult your doctor before breast-feeding.

Our Solodyn (minocycline hydrochloride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Solodyn in Detail - Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • stomach cramps, diarrhea that is watery or bloody;
  • flu symptoms, sores in your mouth and throat;
  • pale or yellowed skin, weakness, dark colored urine, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • fever, skin rash, bruising, severe tingling or numbness, muscle weakness,
  • upper stomach pain, loss of appetite, jaundice (yellowing of the skin or eyes);
  • chest pain, irregular heart rhythm, cough, wheezing, feeling short of breath;
  • confusion, vomiting, swelling, weight gain, urinating less than usual or not at all;
  • headache or pain behind your eyes, ringing in your ears, vision problems;
  • joint pain or swelling with fever, swollen glands, muscle aches, general ill feeling, unusual thoughts or behavior, and/or seizure (convulsions); or
  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious side effects may include:

  • dizziness, tired feeling, spinning sensation;
  • joint or muscle pain;
  • discoloration of you skin or nails;
  • mild nausea, mild diarrhea, upset stomach;
  • mild skin rash or itching;
  • swollen tongue, discoloration of your gums; or
  • vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Solodyn (Minocycline Hydrochloride) »

What is Patient Information Overview?

A concise overview of the drug for the patient or caregiver from First DataBank.

Solodyn Overview - Patient Information: Side Effects

SIDE EFFECTS: Nausea, vomiting, diarrhea, lightheadedness, dizziness, unsteadiness, drowsiness, mild headache, mouth sores, or cough may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: sunburn (sun sensitivity), muscle pain, difficult/painful swallowing, change in the amount of urine, pink urine, brown/gray tooth discoloration, blue/gray/brown discoloration of the skin/lips/tongue/gums, numbness/tingling of the hands/feet, unusual tiredness, stopping of menstrual periods, new signs of infection (e.g., fever, chills, persistent sore throat).

Tell your doctor immediately if any of these rare but very serious side effects occur: hearing changes (e.g., ringing in the ears, decreased hearing), easy bruising/bleeding, unusual/severe headache, vision changes (e.g., blurred vision).

This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Do not use anti-diarrhea products or narcotic pain medications if you have any of the following symptoms because these products may make them worse. Tell your doctor immediately if you develop: persistent diarrhea, abdominal or stomach pain/cramping, blood/mucus in your stool.

Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection (fungal infections). Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, skin lesions/sores, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing, new or worsening swelling/pain in the joints, swollen glands, loss of appetite/weight loss, chest pain, fast/irregular heartbeat, severe stomach/abdominal pain, yellowing eyes/skin, dark urine.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Read the entire patient information overview for Solodyn (Minocycline Hydrochloride)»

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Solodyn FDA Prescribing Information: Side Effects
(Adverse Reactions)

SIDE EFFECTS

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug, and may not reflect the rates observed in practice.

The following table summarizes selected adverse reactions reported in clinical trials at a rate of ≥ 1% for SOLODYN.

Table 2: Selected Treatment-Emergent Adverse Reactions in at least 1% of Clinical Trial Subjects

Adverse Reactions SOLODYN (1 mg/kg)
N = 674 (%)
PLACEBO
N = 364 (%)
At least one treatment emergent event 379 (56) 197 (54)
Headache 152 (23) 83 (23)
Fatigue 62 (9) 24 (7)
Dizziness 59 (9) 17 (5)
Pruritus 31 (5) 16 (4)
Malaise 26 (4) 9 (3)
Mood alteration 17 (3) 9 (3)
Somnolence 13 (2) 3 (1)
Urticaria 10 (2) 1 (0)
Tinnitus 10 (2) 5 (1)
Arthralgia 9 (1) 2 (0)
Vertigo 8 (1) 3 (1)
Dry mouth 7 (1) 5 (1)
Myalgia 7 (1) 4 (1)

Postmarketing Experience

Adverse reactions that have been reported with minocycline hydrochloride use in a variety of indications include:

Skin and hypersensitivity reactions: fixed drug eruptions, balanitis, erythema multiforme, Stevens-Johnson syndrome, anaphylactoid purpura, photosensitivity, pigmentation of skin and mucous membranes, hypersensitivity reactions, angioneurotic edema, anaphylaxis, DRESS syndrome [see WARNINGS AND PRECAUTIONS].

Autoimmune conditions: polyarthralgia, pericarditis, exacerbation of systemic lupus, pulmonary infiltrates with eosinophilia, transient lupus-like syndrome.

Central nervous system: pseudotumor cerebri, bulging fontanels in infants, decreased hearing.

Endocrine: brown-black microscopic thyroid discoloration, abnormal thyroid function. Oncology: thyroid cancer.

Oral: glossitis, dysphagia, tooth discoloration.

Gastrointestinal: enterocolitis, pancreatitis, hepatitis, liver failure.

Renal: reversible acute renal failure.

Hematology: hemolytic anemia, thrombocytopenia, eosinophilia.

Preliminary studies suggest that use of minocycline may have deleterious effects on human spermatogenesis [see Nonclinical Toxicology].

Read the entire FDA prescribing information for Solodyn (Minocycline Hydrochloride) »

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Solodyn - User Reviews

Solodyn User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Solodyn sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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