Solu Cortef
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Solu Cortef
SOLU-CORTEF®
(hydrocortisone sodium succinate) for Injection, USP
For Intravenous or Intramuscular Administration
DRUG DESCRIPTION
SOLU-CORTEF Sterile Powder is an anti-inflammatory glucocorticoid, which contains hydrocortisone sodium succinate as the active ingredient. SOLU-CORTEF Sterile Powder is available in several packages for intravenous or intramuscular administration.
100 mg Plain - Vials containing hydrocortisone sodium succinate equivalent to 100 mg hydrocortisone, also 0.8 mg monobasic sodium phosphate anhydrous, 8.73 mg dibasic sodium phosphate dried. SOLU-CORTEF 100 mg plain does not contain diluent (see DOSAGE AND ADMINISTRATION, Preparation of Solutions).
ACT-O-VIAL® System (Single-Dose Vial) in four strengths:
| 100 mg
ACT-O-VIAL Each 2 mL contains: (when mixed) |
250 mg
ACT-O-VIAL Each 2 mL contains: (when mixed) |
500 mg
ACT-O-VIAL Each 4 mL contains: (when mixed) |
1000 mg
ACT-O-VIAL Each 8 mL contains: (when mixed) |
|
| Hydrocortisone sodium succinate | equiv. to 100 mg Hydrocortisone | equiv. to 250 mg Hydrocortisone | equiv. to 500 mg Hydrocortisone | equiv. to 1000 mg Hydrocortisone |
| Monobasic sodium phosphate anhydrous | 0.8 mg | 2 mg | 4 mg | 8 mg |
| Dibasic sodium phosphate dried | 8.73 mg | 21.8 mg | 44 mg | 87.32 mg |
When necessary, the pH of each formula was adjusted with sodium hydroxide so that the pH of the reconstituted solution is within the USP specified range of 7 to 8.
The chemical name for hydrocortisone sodium succinate is pregn-4-ene-3,20-dione,21(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, monosodium salt, (11β)- and its molecular weight is 484.52.
The structural formula is represented below:
 |
Hydrocortisone sodium succinate is a white or nearly white, odorless, hygroscopic amorphous solid. It is very soluble in water and in alcohol, very slightly soluble in acetone and insoluble in chloroform.
Last reviewed on RxList: 7/12/2010
This monograph has been modified to include the generic and brand name in many instances.
Additional Solu Cortef Information
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