Solu Cortef (Hydrocortisone Sodium Succinate) Patient Information: Side Effects and Drug Images at RxList

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May 27, 2012

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Rheumatoid Arthritis »

Rheumatoid arthritis (RA) facts

Rheumatoid arthritis is an autoimmune disease that can cause chronic inflammation of the joints and other areas of the body.
Rheumatoid arthritis can affect people of all ages.
The cause of rheumatoid arthritis is not known.
Rheumatoid arthritis is a chronic disease, characterized by periods of disease flares and remissions.
In rheumatoid arthritis, multiple joints are usually, but not always, affected in a symmetrical pattern.
Chronic inflammation of rheumatoid arthritis can cause permanent joint destruction and deformity.
Damage to joints can occur early and does not correlate with the severity of symptoms.
The "rheumatoid factor" is an antibody that can be found in the blood of 80% of people with rheumatoid arthritis.
There is no known cure for rheumatoid arthritis.
The treatment of rheumato...

Read the Rheumatoid Arthritis article »

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SOLU-CORTEF®
(hydrocortisone sodium succinate) for Injection, USP

For Intravenous or Intramuscular Administration

DRUG DESCRIPTION

SOLU-CORTEF Sterile Powder is an anti-inflammatory glucocorticoid, which contains hydrocortisone sodium succinate as the active ingredient. SOLU-CORTEF Sterile Powder is available in several packages for intravenous or intramuscular administration.

100 mg Plain - Vials containing hydrocortisone sodium succinate equivalent to 100 mg hydrocortisone, also 0.8 mg monobasic sodium phosphate anhydrous, 8.73 mg dibasic sodium phosphate dried. SOLU-CORTEF 100 mg plain does not contain diluent (see DOSAGE AND ADMINISTRATION, Preparation of Solutions).

ACT-O-VIAL® System (Single-Dose Vial) in four strengths:

	100 mg ACT-O-VIAL Each 2 mL contains: (when mixed)	250 mg ACT-O-VIAL Each 2 mL contains: (when mixed)	500 mg ACT-O-VIAL Each 4 mL contains: (when mixed)	1000 mg ACT-O-VIAL Each 8 mL contains: (when mixed)
Hydrocortisone sodium succinate	equiv. to 100 mg Hydrocortisone	equiv. to 250 mg Hydrocortisone	equiv. to 500 mg Hydrocortisone	equiv. to 1000 mg Hydrocortisone
Monobasic sodium phosphate anhydrous	0.8 mg	2 mg	4 mg	8 mg
Dibasic sodium phosphate dried	8.73 mg	21.8 mg	44 mg	87.32 mg

When necessary, the pH of each formula was adjusted with sodium hydroxide so that the pH of the reconstituted solution is within the USP specified range of 7 to 8.

The chemical name for hydrocortisone sodium succinate is pregn-4-ene-3,20-dione,21(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, monosodium salt, (11β)- and its molecular weight is 484.52.

The structural formula is represented below:

SOLU-CORTEF® (hydrocortisone sodium succinate) Structural Formula Illustration

Hydrocortisone sodium succinate is a white or nearly white, odorless, hygroscopic amorphous solid. It is very soluble in water and in alcohol, very slightly soluble in acetone and insoluble in chloroform.

Last reviewed on RxList: 7/12/2010
This monograph has been modified to include the generic and brand name in many instances.