SOMATULINE DEPOT (lanreotide) Injection 60 mg/0.2 mL, 90 mg/0.3 mL, and 120 mg/0.5 mL is a prolonged-release formulation for deep subcutaneous injection. It contains the drug substance lanreotide acetate, a synthetic octapeptide with a biological activity similar to naturally occurring somatostatin, water for injection and acetic acid (for pH adjustment).
SOMATULINE DEPOT is available as sterile, ready-to-use, single-use prefilled syringes containing lanreotide acetate supersaturated bulk solution of 24.6% w/w lanreotide base.
|Each syringe contains:||SOMATULINE DEPOT 60 mg/0.2 mL||SOMATULINE DEPOT 90 mg/0.3 mL||SOMATULINE DEPOT 120 mg/0.5 mL|
|Lanreotide acetate||77.9 mg||113.6 mg||149.4 mg|
|Water for injection||186. 6 mg||272. 3 mg||357.8 mg|
|Total Weight||266 mg||388 mg||510 mg|
Lanreotide acetate is a synthetic cyclical octapeptide analog of the natural hormone, somatostatin. Lanreotide acetate is chemically known as [cyclo S-S]-3-(2-naphthyl)-D-alanyl-L-cysteinyl-L-tyrosyl-Dtryptophyl-L-lysyl-L-valyl-L-cysteinyl-L-threoninamide, acetate salt. Its molecular weight is 1096.34 (base) and its amino acid sequence is:
For appearance of the formulation, see Dosage Forms and Strengths.
What are the possible side effects of lanreotide (Somatuline Depot)?
Stop using lanreotide and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- slow or uneven heartbeats;
- gallbladder problems (pain in your upper right stomach area with nausea and vomiting);
- thyroid problems (may be detected by blood tests);
- pale skin, weakness, easy bruising or bleeding;
- low blood sugar (headache, confusion, drowsiness, weakness,...
Last reviewed on RxList: 1/5/2015
This monograph has been modified to include the generic and brand name in many instances.
Additional Somatuline Depot Information
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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