home > drugs a-z list > sporanox (itraconazole capsules) drug center > sporanox (itraconazole capsules) drug - overdosage and contraindications

Recommended Topic Related To:

Sporanox

Ringworm »

Ringworm facts

  • Ringworm is a common fungal infection of the skin and is not due to a worm.
  • The medical term for ringworm is tinea. The condition is further named for the site of the body where the infection occurs.
  • Ringworm causes a scaly, crusted rash that may itch.
  • Ringworm can be successfully treated with antifungal medications used either topically or orally.

What does the term ringworm mean?

The term ringworm or ringworms refers to fungal infections that are on the surface of the skin. The name is derived from the early belief that the infection was due to a worm, which it is not. Ringworm is a fungal infection in the skin. Nevertheless, the name ringworm remains. Some of these fungi produce round spots on the skin, but many do not. On the other hand, many round, red spots on the skin are not due to a fungal infection. A physical examination of the affected s...

Read the Ringworm article »

Sporanox

font size

OVERDOSE

Itraconazole is not removed by dialysis. In the event of accidental overdosage, supportive measures, including gastric lavage with sodium bicarbonate, should be employed.

Limited data exist on the outcomes of patients ingesting high doses of itraconazole. In patients taking either 1000 mg of SPORANOX® (itraconazole) Oral Solution or up to 3000 mg of SPORANOX® (itraconazole) Capsules, the adverse event profile was similar to that observed at recommended doses.

CONTRAINDICATIONS

Congestive Heart Failure

SPORANOX® (itraconazole) Capsules should not be administered for the treatment of onychomycosis in patients with evidence of ventricular dysfunction such as congestive heart failure (CHF) or a history of CHF. (See CLINICAL PHARMACOLOGY: Special Populations, WARNINGS, PRECAUTIONS: DRUG INTERACTIONS-Calcium Channel Blockers, and ADVERSE REACTIONS: Post-marketing Experience.)

Drug Interactions

Concomitant administration of SPORANOX® (itraconazole) Capsules, Injection, or Oral Solution and certain drugs metabolized by the cytochrome P450 3A4 isoenzyme system (CYP3A4) may result in increased plasma concentrations of those drugs, leading to potentially serious and/or life-threatening adverse events. Cisapride, oral midazolam, nisoldipine, pimozide, quinidine, dofetilide, triazolam and levacetylmethadol (levomethadyl) are contraindicated with SPORANOX® (itraconazole capsules) . HMG CoA-reductase inhibitors metabolized by CYP3A4, such as lovastatin and simvastatin, are also contraindicated with SPORANOX® (itraconazole capsules) . Ergot alkaloids metabolized by CYP3A4 such as dihydroergotamine, ergometrine (ergonovine), ergotamine and methylergometrine (methylergonovine) are contraindicated with SPORANOX®. (See BOX WARNING, and PRECAUTIONS: DRUG INTERACTIONS.)

SPORANOX® (itraconazole capsules) should not be administered for the treatment of onychomycosis to pregnant patients or to women contemplating pregnancy.

SPORANOX® (itraconazole capsules) is contraindicated for patients who have shown hypersensitivity to itraconazole or its excipients. There is no information regarding cross-hypersensitivity between itraconazole and other azole antifungal agents. Caution should be used when prescribing SPORANOX® (itraconazole capsules) to patients with hypersensitivity to other azoles.

Last reviewed on RxList: 8/23/2010
This monograph has been modified to include the generic and brand name in many instances.

Additional Sporanox Information

Sporanox - User Reviews

Sporanox User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Sporanox sorted by most helpful. Patient Discussions FAQs

See User Reviews

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Privacy Policy

Women's Health

Find out what women really need.


From WebMD

Infectious Disease Resources
Featured Centers
Health Solutions From Our Sponsors