"The U.S. Food and Drug Administration today approved Iclusig (ponatinib) to treat adults with chronic myeloid leukemia (CML) and Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL), two rare blood and bone marrow diseases."...
Sprycel Consumer (continued)
Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.
This drug should not be used with the following product because very serious interactions may occur: St John's wort.
If you are currently using the medication listed above, tell your doctor or pharmacist before starting dasatinib.
Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: "blood thinners" (e.g., warfarin, aspirin), H2 blockers (e.g., cimetidine, famotidine, ranitidine), proton pump inhibitors (e.g., lansoprazole, omeprazole, pantoprazole), drugs affecting liver enzymes that remove dasatinib from your body (such as azole antifungals including itraconazole/ketoconazole, corticosteroids including dexamethasone, HIV protease inhibitors including ritonavir/saquinavir, macrolide antibiotics including erythromycin, rifamycins including rifampin/rifabutin, certain anti-seizure medicines including carbamazepine/phenytoin, telithromycin).
If your doctor has prescribed low doses of aspirin to prevent heart attack or stroke (usually at dosages of 81-325 milligrams a day), you should continue to take the aspirin. Consult your doctor or pharmacist for more details.
Avoid taking this medication at the same time as antacids. Wait at least 2 hours between taking this medication and an antacid. (See also How to Use section.)
This drug can slow down the removal of other drugs from your body by affecting certain liver enzymes. These affected drugs include cyclosporine, ergotamine, fentanyl, simvastatin, and tacrolimus, among others. Ask your doctor about using these drugs safely.
Many drugs besides dasatinib may affect the heart rhythm (QT prolongation), including amiodarone, dofetilide, pimozide, procainamide, quinidine, sotalol, macrolide antibiotics (such as erythromycin), among others. Therefore, before using dasatinib, report all medications you are currently using to your doctor or pharmacist.
This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.
OVERDOSE: If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
NOTES: Do not share this medication with others.
Laboratory and/or medical tests (e.g., magnesium/potassium blood levels, complete blood count, liver function tests) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.
MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
STORAGE: Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Do not store in the bathroom. Keep all medicines away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
MEDICAL ALERT: Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada).
Information last revised June 2013. Copyright(c) 2013 First Databank, Inc.
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