In this Article

• What is dasatinib (Sprycel)?
• What are the possible side effects of dasatinib (Sprycel)?
• What is the most important information I should know about dasatinib (Sprycel)?
• What should I discuss with my health care provider before taking dasatinib (Sprycel)?
• How should I take dasatinib (Sprycel)?
• What happens if I miss a dose (Sprycel)?
• What happens if I overdose (Sprycel)?
• What should I avoid while taking dasatinib (Sprycel)?
• What other drugs will affect dasatinib (Sprycel)?
• Where can I get more information?

What should I discuss with my health care provider before taking dasatinib (Sprycel)?

You should not use dasatinib if:

• you have not first received a medication called imatinib (Gleevec); or
• if you are pregnant or planning to become pregnant during treatment with dasatinib.

To make sure you can safely take dasatinib, tell your doctor if you have any of these other conditions:

• low levels of potassium or magnesium in your blood;
• anemia (lack of red blood cells);
• liver disease;
• lung disease;
• heart disease or a heart rhythm disorder; or
• a personal or family history of Long QT syndrome.

FDA pregnancy category D. Do not use dasatinib if you are pregnant. It could harm the unborn baby. Tell your doctor if you become pregnant during treatment.

Use birth control to prevent pregnancy while you are receiving dasatinib, whether you are a man or a woman. Dasatinib use by either parent may cause birth defects. A man taking dasatinib should use a condom during any sexual activity.

This medication may affect fertility (your ability to have children), whether you are a man or a woman.

It is not known whether dasatinib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while taking dasatinib.

Dasatinib tablets contain lactose. Talk to your doctor before using this medication if you are lactose-intolerant.

How should I take dasatinib (Sprycel)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

This medicine is usually taken once per day in the morning or evening. Follow your doctor's instructions. You may take the medication with or without food.

Your doctor may occasionally change your dose to make sure you get the best results.

Do not crush, chew, or break a dasatinib tablet. Swallow it whole. Breaking the pill may cause too much of the drug to be released at one time.

Do not use a pill that has been accidentally broken. The medicine from a crushed or broken pill can be dangerous if it gets in your eyes, mouth, or nose, or on your skin. If this occurs, wash your skin with soap and water or rinse your eyes with water. Ask your doctor or pharmacist how to safely handle and dispose of a broken tablet.

Dasatinib can lower blood cells that help your body fight infections. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests. Visit your doctor regularly.

Store at room temperature away from moisture and heat.