"Using data from over 18,000 patients, scientists have identified more than two dozen genetic risk factors involved in Parkinson's disease, including six that had not been previously reported. The study, published in Nature Genetics, was partially"...
(carbidopa, levodopa and entacapone) Tablets
Stalevo is a combination of carbidopa, levodopa, and entacapone for the treatment of Parkinson's disease.
Carbidopa, an inhibitor of aromatic amino acid decarboxylation, is a white, crystalline compound, slightly soluble in water, with a molecular weight of 244.3. It is designated chemically as (-)-L-(&apha;-hydrazino-(&apha;-methyl-β-(3,4-dihydroxybenzene) propanoic acid monohydrate. Its empirical formula is C10H14N2O4•H2O, and its structural formula is:
Tablet content is expressed in terms of anhydrous carbidopa, which has a molecular weight of 226.3.
Levodopa, an aromatic amino acid, is a white, crystalline compound, slightly soluble in water, with a molecular weight of 197.2. It is designated chemically as (-)-L-&apha;-amino-β-(3,4-dihydroxybenzene) propanoic acid. Its empirical formula is C9H11NO4, and its structural formula is:
Entacapone, a COMT inhibitor, is a nitro-catechol-structured compound with a molecular weight of 305.3. The chemical name of entacapone is (E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide. Its empirical formula is C14H15N3O5 and its structural formula is:
Stalevo is supplied as tablets in 6 strengths:
Stalevo 50:12.5 mg of carbidopa, 50 mg of levodopa and 200 mg of entacapone
Stalevo 75: 18.75 mg of carbidopa, 75 mg of levodopa and 200 mg of entacapone
Stalevo 100: 25 mg of carbidopa, 100 mg of levodopa and 200 mg of entacapone
Stalevo125: 31.25 mg of carbidopa, 125 mg of levodopa and 200 mg of entacapone
Stalevo 150: 37.5 mg of carbidopa, 150 mg of levodopa and 200 mg of entacapone
Stalevo 200: 50 mg of carbidopa, 200 mg of levodopa and 200 mg of entacapone
Inactive Ingredients: corn starch, croscarmellose sodium, glycerol 85%, hypromellose, magnesium stearate, mannitol, polysorbate 80, povidone, sucrose, red iron oxide, and titanium dioxide. Stalevo 50, Stalevo 100, and Stalevo 150 also contain yellow iron oxide.
What are the possible side effects of carbidopa, entacapone, and levodopa?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- nausea, sweating, feeling like you might pass out (especially when you first start taking this medication);
- depression, confusion, hallucinations, unusual thoughts or behavior, thoughts about hurting yourself;
- worsening symptoms such as tremors, twitching or uncontrollable movements of your eyes, lips, tongue,...
What are the precautions when taking carbidopa, levodopa and entacapone (Stalevo)?
Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, glaucoma, breathing problems, heart disease (especially history of heart attack), kidney disease, ulcers, mental/mood disorders (e.g., depression, schizophrenia), blood disorders, sleep disorders.
To minimize dizziness and lightheadedness, get up slowly when rising from a seated or lying position.
This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that...
Last reviewed on RxList: 2/10/2016
This monograph has been modified to include the generic and brand name in many instances.
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