June 26, 2016
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Staticin

CLINICAL PHARMACOLOGY

The exact mechanism by which erythromycin re-duces lesions of acne vulgaris is not fully known; however, the effect appears to be due in part to the antibacterial activity of the drug.

Microbiology

Erythromycin acts by inhibition of protein synthesis in susceptible organisms by reversibly binding to 50 S ribosomal subunits, thereby inhibiting translo-cation of aminoacyl transfer-RNA and inhibiting polypeptide synthesis. Antagonism has been demonstrated in vitro between erythromycin, and lincomycin, chloramphenicol, and clindamycin.

Last reviewed on RxList: 2/3/2009
This monograph has been modified to include the generic and brand name in many instances.

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