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Stem Cells (cont.)

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Peripheral blood stem cells

Most blood stem cells are present in the bone marrow, but a few are present in the bloodstream. This means that these so-called peripheral blood stem cells (PBSCs) can be isolated from a drawn blood sample. The blood stem cell is capable of giving rise to a very large number of very different cells that make up the blood and immune system, including red blood cells, platelets, granulocytes, and lymphocytes.

  • Red blood cells carry oxygen around the body and give the blood its color.
  • Platelets are cell fragments that stop a person from bleeding and help the body to clot and heal when it is cut.
  • Granulocytes are a type of white blood cell that helps fight bacterial infection.
  • Lymphocytes are a type of white blood cell that is part of the immune system, help fight other infections, and also may be involved in protection againstcancer.

All of these very different cells with very different functions are derived from a common, ancestral, committed blood-forming (hematopoietic), stem cell.

Umbilical cord stem cells

Blood from the umbilical cord contains some stem cells that are genetically identical to the newborn. Like adult stem cells, these are multipotent stem cells that are able to differentiate into certain, but not all, cell types. For this reason, umbilical cord blood is often banked, or stored, for possible future use should the individual require stem cell therapy.

Induced pluripotent stem cells

Induced pluripotent stem cells (iPSCs) were first created for human cells in 2007. These are adult cells that have been genetically converted to an embryonic stem cell–like state. In animal studies, iPSCs have been shown to possess characteristics of pluripotent stem cells. Human iPSCs can differentiate and become multiple different fetal cell types. iPSCs are valuable aids in the study of disease development and drug treatment, and they may have future uses in transplantation medicine. Further research is needed regarding the development and use of these cells.

Medically Reviewed by a Doctor on 1/23/2014

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Source: MedicineNet.com
http://www.medicinenet.com/stem_cells/article.htm

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