Stimate (Desmopressin Acetate Nasal Spray) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

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Hemophilia »

What is hemophilia?

Hemophilia is not one disease but rather one of a group of inherited bleeding disorders that cause abnormal or exaggerated bleeding and poor blood clotting. The term is most commonly used to refer to two specific conditions known as hemophilia A and hemophilia B, which will be the main subjects of this article. Hemophilia A and B are distinguished by the specific gene that is mutated (altered to become defective) and codes for a defective clotting factor (protein) in each disease. Rarely, hemophilia C is encountered, but its effect on clotting is far less pronounced than A or B.

Hemophilia A and B are inherited in an X-linked recessive genetic pattern and are therefore much more common in males. This pattern of inheritance means that a given gene on the X chromosome expresses itself only when there is no normal gene present. For example, a boy has only one X chromosome, so a boy with hemophilia has the defective gene on his...

Read the Hemophilia article »

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Stimate®
(desmopressin acetate) Nasal Spray, 1.5 mg/mL

DRUG DESCRIPTION

Stimate® (desmopressin acetate) is a synthetic analogue of the natural pituitary hormone 8 arginine vasopressin (ADH), an antidiuretic hormone affecting renal water conservation. Stimate® Nasal Spraycontains 1.5 mg/mL desmopressin acetate in an aqueous solution at a pH of approximately 5.0. Stimate® Nasal Spray's compression pump delivers 0.1 mL (150 mcg) of solution per spray. It is chemically defined as follows:

Mol. Wt. 1183.34 Empirical formula: C₄₆H₆₄N₁₄O₁₂S₂ •C₂H₄O₂•3H₂O

1-(3-mercaptopropionic acid)-8-D-arginine vasopressin monoacetate (salt) trihydrate.

Stimate® Nasal Spray is provided as an aqueous solution for intranasal use.

Each mL contains:
Active ingredient:
Desmopressin acetate	1.5 mg
Inactive ingredients:
Sodium chloride	7.5 mg
Buffer:
Citric acid monohydrate	1.7 mg
Disodium phosphate dihydrate	3.0 mg
Preservative:
Benzalkonium chloride	0.1 mg
Purified water	To 1 mL

What are the possible side effects of desmopressin nasal (DDAVP Nasal, DDAVP Rhinal Tube, Stimate)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using desmopressin nasal and call your doctor at once if you have any of these serious side effects:

nausea, vomiting, weakness, loss of appetite, headache, feeling restless or irritable, confusion, hallucinations, muscle pain or weakness, and/or seizure;
feeling like you might pass out;

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What are the precautions when taking desmopressin acetate nasal spray (Stimate)?

Before using desmopressin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: kidney disease, a low level of sodium in the blood (current or past hyponatremia).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: high blood pressure, heart disease (such as blocked blood vessels in the heart), conditions that may increase your risk of fluid/mineral imbalance (such as cystic fibrosis, heart failure),...

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Last reviewed on RxList: 10/3/2011
This monograph has been modified to include the generic and brand name in many instances.