"In a response to mounting evidence, the US Food and Drug Administration (FDA) announced that the diabetes drug metformin can be used safely in patients with mild and, in some cases, moderate kidney impairment after decades of warning against it. "...
(desmopressin acetate) Nasal Spray, 1.5 mg/mL
Stimate® (desmopressin acetate) is a synthetic analogue of the natural pituitary hormone 8-arginine vasopressin (ADH), an antidiuretic hormone affecting renal water conservation. Stimate® Nasal Spray contains 1.5 mg/mL desmopressin acetate in an aqueous solution at a pH of approximately 5.0. Stimate® Nasal Spray's compression pump delivers 0.1 mL (150 mcg) of solution per spray. It is chemically defined as follows:
Mol. Wt. 1183.34 Empirical formula: C46H64N14O12S2 •C2H4O2•3H2O
1-(3-mercaptopropionic acid)-8-D-arginine vasopressin monoacetate (salt) trihydrate.
Stimate® Nasal Spray is provided as an aqueous solution for intranasal use.
Each mL contains:
|Desmopressin acetate||1.5 mg|
|Sodium chloride||7.5 mg|
|Citric acid monohydrate||1.7 mg|
|Disodium phosphate dihydrate||3.0 mg|
|Benzalkonium chloride||0.1 mg|
|Purified water||To 1 mL|
What are the possible side effects of desmopressin nasal (DDAVP Nasal, DDAVP Rhinal Tube, Stimate)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using desmopressin nasal and call your doctor at once if you have any of these serious side effects:
- nausea, vomiting, weakness, loss of appetite, headache, feeling restless or irritable, confusion, hallucinations, muscle pain or weakness, and/or seizure;
- feeling like you might pass out;
- chest pain, fast or pounding heart...
What are the precautions when taking desmopressin acetate nasal spray (Stimate)?
Before using desmopressin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: kidney disease, a low level of sodium in the blood (current or past hyponatremia).
Before using this medication, tell your doctor or pharmacist your medical history, especially of: high blood pressure, heart disease (such as blocked blood vessels in the heart), conditions that may increase your risk of fluid/mineral imbalance (such as cystic fibrosis, heart failure),...
Last reviewed on RxList: 6/17/2013
This monograph has been modified to include the generic and brand name in many instances.
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