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Stimate Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Stimate (desmopressin acetate) nasal is used to treat central cranial diabetes insipidus, and increased thirst and urination caused by head surgery or head trauma. It is also used to treat hemophilia A or von Willebrand's disease Type I. It is a man-made form of a hormone that occurs naturally in the pituitary gland. Common side effects include headache, runny/stuffy nose, nausea, upset stomach, or flushing of the face.
The recommended dose of Stimate Nasal Spray is to administer one spray per nostril, to provide a total dose of 300 mcg. Stimate may interact with carbamazepine, chlorpromazine, lamotrigine, oxybutynin, vasopressin, narcotics, antidepressants, medicines to treat erectile dysfunction, drugs to treat high blood pressure or a prostate disorder, beta-blockers, or NSAIDs (nonsteroidal anti-inflammatory drugs). Tell your doctor all medications and supplements you use. During pregnancy, Stimate should be used only when prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.
Our Stimate (desmopressin acetate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Stimate in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using desmopressin nasal and call your doctor at once if you have any of these serious side effects:
- nausea, vomiting, weakness, loss of appetite, headache, feeling restless or irritable, confusion, hallucinations, muscle pain or weakness, and/or seizure;
- feeling like you might pass out;
- chest pain, fast or pounding heart rate;
- vaginal pain;
- nosebleed; or
- dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).
Less serious side effects may include:
- runny or stuffy nose;
- sore throat, cough, or other cold symptoms;
- eye redness or watering;
- eye itching or increased sensitivity to light;
- headache, weakness;
- feeling dizzy or agitated;
- nausea, vomiting, stomach pain;
- hot or cold feeling; or
- warmth, redness, or tingly feeling in your face.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Stimate (Desmopressin Acetate Nasal Spray) »
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Stimate Overview - Patient Information: Side Effects
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Desmopressin reduces the amount of urine your kidneys make. It may affect the balance of water and minerals in your body. Desmopressin can infrequently cause a low level of sodium in the blood, which can be serious and possibly life-threatening. Drinking too much water or other fluids increases the risk of having a low level of sodium in the blood. Therefore, follow your doctor's directions for limiting fluids. Seek immediate medical attention if you have any of these unlikely but serious symptoms of a low level of sodium in the blood: loss of appetite, severe nausea, vomiting, severe headache, muscle weakness/spasms/cramps, sudden weight gain, unusual tiredness, unusual severe drowsiness, mental/mood changes (such as confusion, hallucinations, irritability), loss of consciousness, seizures, slow/shallow breathing.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Stimate (Desmopressin Acetate Nasal Spray)»
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Stimate FDA Prescribing Information: Side Effects
Infrequently, DDAVP® Injection has produced transient headache, nausea, mild abdominal cramps and vulval pain. These symptoms disappeared with reduction in dosage. Occasional facial flushing has been reported with the administration of DDAVP® Injection. Infrequently, high doses of intranasal DDAVP® have produced transient headache and nausea. Nasal congestion, rhinitis and flushing have also been reported occasionally along with mild abdominal cramps. These symptoms disappeared with reduction in dosage. Nosebleed, sore throat, cough and upper respiratory infections have also been reported.
In addition to those listed above, the following have also been reported in clinical trials with Stimate® Nasal Spray: Somnolence, dizziness, itchy or light-sensitive eyes, insomnia, chills, warm feeling, pain, chest pain, palpitations, tachycardia, dyspepsia, edema, vomiting, agitation and balanitis.
DDAVP® Injection (desmopressin acetate) has infrequently produced changes in blood pressure causing either a slight elevation or a transient fall with a compensatory increase in heart rate. Severe allergic reactions including anaphylaxis have been reported rarely with DDAVP® Injection.
There have been rare reports of convulsions from hyponatremia associated with concomitant use of desmopressin and the following medications: oxybutynin and imipramine. See WARNINGS for the possibility of water intoxication, hyponatremia and coma.
To report SUSPECTED ADVERSE REACTIONS, contact CSL Behring Pharmacovigilance at 1-866-915-6958 or FDA at 1-800-FDA-1088 or www. fda.gov/medwatch.
Read the entire FDA prescribing information for Stimate (Desmopressin Acetate Nasal Spray) »
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