Melissa Conrad Stöppler, MD
Melissa Conrad Stöppler, MD, is a U.S. board-certified Anatomic Pathologist with subspecialty training in the fields of Experimental and Molecular Pathology. Dr. Stöppler's educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology.
Roxanne Dryden-Edwards, MD
Dr. Roxanne Dryden-Edwards is an adult, child, and adolescent psychiatrist. She is a former Chair of the Committee on Developmental Disabilities for the American Psychiatric Association, Assistant Professor of Psychiatry at Johns Hopkins Hospital in Baltimore, Maryland, and Medical Director of the National Center for Children and Families in Bethesda, Maryland.
In this Article
- Stress facts
- What is stress?
- A brief history of stress
- What are the signs and symptoms of poorly managed stress?
- Who is most vulnerable to stress?
- Teen stress
- What is the healthy response to stress?
- How does the response to stress work?
- What is the role of the hypothalamus-pituitary-adrenal (HPA) axis (grouping) in stress?
- What is the role of the locus coeruleus in stress?
- How do the connections in the brain work in stress?
- What do we know about using (activating) and overusing our internal systems that respond to stress?
- What are the effects of stress on medical and psychological conditions?
- Conclusions about the effects of stress
- What can people do for stress management?
- What's in the future for stress?
- Diet for Stress Management Slideshow
- Take the Stress Quiz!
- Tips for Exercise, Diet and Stress Reduction Slideshow
- Stress Rxlist FAQs
- Find a local Psychiatrist in your town
What is the role of the locus coeruleus in stress?
The locus coeruleus has many connections to other parts of the brain, particularly areas that bring in and process sensory information (information from sight, hearing, smell, taste, and touch). The locus coeruleus secretes norepinephrine and stimulates other brain centers to do the same. It is like the pacemaker (meaning it controls the tempo) of the brain. Thus, it increases arousal (heightened awareness, alertness) and vigilance (watchfulness, carefulness) and adjusts (modulates) the action of the autonomic nervous system, which includes the SNS. The autonomic nervous system regulates blood flow, heart rate, blood pressure, and breathing (respiration). It can also temporarily shut down the gastrointestinal (GI) and sexual systems until the crisis or stressful event is over. These initial reactions, to get our blood flowing, heart pumping, and muscles energized, occur very quickly and automatically.
How do the connections in the brain work in stress?
The HPA axis and the locus coeruleus systems are linked through the hypothalamus and an area of the brain known as the limbic system. The limbic system is the control area for emotion and the processing area for memory. These linkages are critical. For example, if you see the bushes rustling, your locus coeruleus immediately gets the stress response rolling. However, when you see that it is not a mountain lion but a golden retriever in the bushes, your memory of the tameness of the dog will turn off the stress response. Similarly, if a person is nervous before a public-speaking engagement and the first minute or two goes well, this happy feeling will turn down the activity of the locus coeruleus. These internal adjustments are why experienced public speakers often start off with a joke. It's as much to calm themselves (if the joke goes well) as it is to entertain you.
The connections also include the endogenous (within the body) opiate (opium-like) system and the reward (dopamine) system. Thereby, during stress, pain is reduced and an extremely happy feeling (euphoria) may result. These connections partially account for "runner's high" and have a great deal to do with why we like roller coasters and scary movies.
Here's how the connections work. The limbic system performs an emotional analysis and memory review of the information provided by the senses. Then, the multiplicity of connections allows us to determine whether the current stress is
- one that has been mastered in the past and successfully adapted to,
- not a threat at all,
- a clear and present danger.
All of this internal activity must occur in milliseconds, and it does.
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