Stromectol (Ivermectin) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Stromectol

Scabies »

Scabies facts

Scabies is an itchy, highly contagious skin condition caused by an infestation by the itch mite Sarcoptes scabiei.
Direct skin-to-skin contact is the mode of transmission.
A severe and relentless itch is the predominant symptom of scabies.
Sexual contact is the most common form of transmission among sexually active young people, and scabies has been considered by many to be a sexually transmitted disease (STD).
Scabies produces a skin rash composed of small red bumps and blisters and affects specific areas of the body.
Treatment includes oral or topical scabicidal drugs.

What is scabies?

Scabies is an itchy, highly contagious skin disease caused by an infestation by the itch mite Sarcoptes scabiei. Mites are small eight-legged parasites (in contrast to insects, which have six legs). They are tiny, just 1/3 millimeter long, and burrow into the sk...

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STROMECTOL®
(ivermectin)

DRUG DESCRIPTION

STROMECTOL (Ivermectin) is a semisynthetic, anthelmintic agent for oral administration. Ivermectin is derived from the avermectins, a class of highly active broad-spectrum, anti-parasitic agents isolated from the fermentation products of Streptomyces avermitilis. Ivermectin is a mixture containing at least 90% 5-O demethyl-22,23-dihydroavermectin A_1a and less than 10% 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)avermectin A_1a, generally referred to as 22,23-dihydroavermectin B_1a and B_1b, or H₂B_1a and H₂B_1b, respectively. The respective empirical formulas are C₄₈H₇₄O₁₄ and C₄₇H₇₂O₁₄, with molecular weights of 875.10 and 861.07, respectively. The structural formulas are:

STROMECTOL®
(Ivermectin) Structural Formula Illustration

Component B_1a, R = C₂H₅.............................Component B_1b, R = CH₃

Ivermectin is a white to yellowish-white, nonhygroscopic, crystalline powder with a melting point of about 155°C. It is insoluble in water but is freely soluble in methanol and soluble in 95% ethanol.

STROMECTOL (ivermectin) is available in 3-mg tablets containing the following inactive ingredients: microcrystalline cellulose, pregelatinized starch, magnesium stearate, butylated hydroxyanisole, and citric acid powder (anhydrous).

What are the possible side effects of ivermectin (Stromectol)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

vision changes or problems with your vision;
urinary or bowel problems;
weakness, confusion, lack of coordination;
eye redness, swelling, or pain; or
seizure (convulsions).

Other less serious side effects may be more likely to occur,...

Read All Potential Side Effects and See Pictures of Stromectol »

What are the precautions when taking ivermectin (Stromectol)?

Before taking ivermectin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver problems.

If you have traveled or lived in West or Central Africa, you may be infected with certain parasites (such as Loa loa, African trypanosomiasis) that could cause problems with ivermectin treatment. These effects could rarely result in serious (possibly fatal) effects on the brain (such as encephalopathy). Consult your doctor for more information.

This drug may make you dizzy. Do not drive, use...

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Last reviewed on RxList: 1/6/2010
This monograph has been modified to include the generic and brand name in many instances.