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- Clinician Information:
Subutex Patient Information including If I Miss a Dose
In this Article
- What is buprenorphine (Subutex)?
- What are the possible side effects of buprenorphine (Subutex)?
- What is the most important information I should know about buprenorphine (Subutex)?
- What should I discuss with my healthcare provider before taking buprenorphine (Subutex)?
- How should I take buprenorphine (Subutex)?
- What happens if I miss a dose (Subutex)?
- What happens if I overdose (Subutex)?
- What should I avoid while taking buprenorphine (Subutex)?
- What other drugs will affect buprenorphine (Subutex)?
- Where can I get more information?
What happens if I miss a dose (Subutex)?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose (Subutex)?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of buprenorphine can be fatal.
Overdose symptoms may include extreme drowsiness or weakness, cold or clammy skin, pinpoint pupils, fainting, slow heart rate, weak pulse, weak or shallow slowed breathing (breathing may stop).
What should I avoid while taking buprenorphine (Subutex)?
Avoid drinking alcohol, which can increase some of the side effects of buprenorphine. Using too much of this medicine in addition to drinking alcohol can cause death.
Buprenorphine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
What other drugs will affect buprenorphine (Subutex)?
Do not take buprenorphine with any other narcotic pain medications, sedatives, tranquilizers, sleeping pills, muscle relaxers, or other medicines that can make you sleepy or slow your breathing. Dangerous side effects may result.
Tell your doctor about all other medicines you use, especially:
- conivaptan (Vaprisol);
- imatinib (Gleevec);
- isoniazid (for treating tuberculosis);
- an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), rifampin (Rifadin, Rifater, Rifamate, Rimactane), or telithromycin (Ketek);
- antifungal medication such as itraconazole (Sporanox), ketoconazole (Nizoral), or miconazole (Oravig);
- heart or blood pressure medication such as nicardipine (Cardene) or quinidine (Quin-G);
- HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase), or ritonavir (Norvir, Kaletra); or
- a sedative such as diazepam (Valium), midazolam (Versed), alprazolam (Xanax) lorazepam (Ativan), clorazepate (Tranxene), triazolam (Halcion), flurazepam (Dalmane), or temazepam (Restoril).
This list is not complete and other drugs may interact with buprenorphine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Where can I get more information?
Your pharmacist has information about buprenorphine written for health professionals that you may read.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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Additional Subutex Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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