Sucraid® (sacrosidase) oral solution is an enzyme replacement therapy for the treatment of the genetically determined sucrase deficiency, which is part of congenital sucrase-isomaltase deficiency (CSID).

Sucraid® (sacrosidase oral solution) is a pale yellow, clear solution with a pleasant sweet taste. Each milliliter (mL) of Sucraid (sacrosidase oral solution) ® contains 8,500 International Units (I.U) of the enzyme sacrosidase, the active ingredient. The chemical name of this enzyme is ß,D-fructofuranoside fructohydrolase. The enzyme is derived from baker's yeast (saccharomyces cerevisiae). It has been reported that the primary amino acid structure of this protein consists of 513 amino acids with an apparent molecular weight of 100,000 g/mole for the glycosolated monomer (range 66,000-116,000 g/mole). Reports also suggest that the protein exists in solution as a monomer, dimmer, tetramer, and octomer ranging from 100,000 g/mole to 800,000 g/mole. It has an isoelectric point of 4 (pl=4.093).

Sucraid® (sacrosidase oral solution) also contains 50% glycerol in an aqueous solution. Glycerol (glycerin) in the amount consumed in the recommended doses of Sucraid® (sacrosidase oral solution) has no expected toxicity.
This enzyme preparation is fully soluble with water, milk, and infant formula

(DO NOT HEAT SOLUTIONS CONTAINING Sucraid® (sacrosidase oral solution) ). Do not put Sucraid (sacrosidase oral solution) ® in warm or hot liquids.

Last reviewed on RxList: 2/13/2009
This monograph has been modified to include the generic and brand name in many instances.