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There is no experience with nisoldipine overdosage. Generally, overdosage with other dihydropyridines leading to pronounced hypotension calls for active cardiovascular support including monitoring of cardiovascular and respiratory function, elevation of extremities, judicious use of calcium infusion, pressor agents and fluids. Clearance of nisoldipine would be expected to be slowed in patients with impaired liver function. Since nisoldipine is highly protein bound, dialysis is not likely to be of any benefit; however, plasmapheresis may be beneficial.
SULAR (nisoldipine) is contraindicated in patients with known hypersensitivity to dihydropyridine calcium channel blockers.
Last reviewed on RxList: 1/25/2008
This monograph has been modified to include the generic and brand name in many instances.
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