July 31, 2016

Sulfamylon Cream

(mafenide acetate) Cream, USP

Topical Antibacterial Agent for Adjunctive Therapy In Second- and Third-Degree Burns


SULFAMYLON Cream (mafenide acetate cream) is a soft, white, nonstaining, water-miscible, anti-infective cream for topical administration to burn wounds.

SULFAMYLON Cream (mafenide acetate cream) spreads, easily, and can be washed off readily with water. It has a slight acetic odor. Each gram of SULFAMYLON Cream (mafenide acetate cream) contains mafenide acetate equivalent to 85 mg of the base. The cream vehicle consists of cetyl alcohol, steryl alcohol, cetyl esters wax, polyoxyl 40 stearate, polyoxyl 8 stearate, glycerin, and water, with methylparaben, propylparaben, sodium metabisulfite, and edetate disodium as preservatives.

Chemically, mafenide acetate is α-Amino-p-toluenesulonamide mono acetate and has the following structural formula:

SULFAMYLON (mafenide acetate) structural formula illustration

What are the possible side effects of mafenide (Sulfamylon)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have a serious side effect such as:

  • pale or yellowed skin, dark colored urine, fever, confusion or weakness;
  • chest pain, fast or pounding heartbeats, headache, confusion;
  • nausea, vomiting, stomach pain, appetite changes, muscle weakness, bone pain, and weight loss;
  • rapid breathing, gasping, or feeling short of breath; or
  • severe skin rash,...

Read All Potential Side Effects and See Pictures of Sulfamylon Cream »

Last reviewed on RxList: 7/17/2008
This monograph has been modified to include the generic and brand name in many instances.

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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