July 25, 2016

Sulfamylon Cream

Sulfamylon Cream Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 5/12/2016

Sulfamylon Cream (mafenide acetate) is a topical (for the skin) antibiotic used to prevent infection in severe burn wounds. Common side effects of Sulfamylon Cream include:

  • pain or burning of treated areas
  • redness
  • itching, or
  • skin rash

Sulfamylon Cream is applied with a sterile gloved hand. The recommended dose is to apply the cream once or twice daily, to a thickness of approximately 1/16 inch. The burned areas should be covered with Sulfamylon Cream at all times. It is not likely other drugs you take orally or inject will have an effect on topically applied Sulfamylon Cream. But many drugs can interact with each other. Tell your doctor all medications and supplements you use. During pregnancy, Sulfamylon Cream should be used only when prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Our Sulfamylon Cream (mafenide acetate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Sulfamylon Cream in Detail - Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have a serious side effect such as:

  • pale or yellowed skin, dark colored urine, fever, confusion or weakness;
  • chest pain, fast or pounding heartbeats, headache, confusion;
  • nausea, vomiting, stomach pain, appetite changes, muscle weakness, bone pain, and weight loss;
  • rapid breathing, gasping, or feeling short of breath; or
  • severe skin rash, bruising, severe tingling, numbness, or pain.

Less serious side effects may include:

  • mild skin rash, redness, or itching; or
  • pain or burning of treated skin areas.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Sulfamylon Cream (Mafenide Acetate Cream)

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Sulfamylon Cream FDA Prescribing Information: Side Effects
(Adverse Reactions)


It is frequently difficult to distinguish between an adverse reaction to SULFAMYLON Cream (mafenide acetate cream) and the effect of a severe burn. A single case of bone marrow depression and a single case of acute attack of porphyria have been reported following therapy with SULFAMYLON Cream (mafenide acetate cream) . Fatal hemolytic anemia with disseminated intravascular coagulation, presumably related to a glucose-6-phosphate dehydrogenase deficiency, has been reported following therapy with SULFAMYLON Cream (mafenide acetate cream) .

Dermatologic: The most frequently reported reaction was pain on application or a burning sensation. Rare occurrences are excoriation of new skin and bleeding of skin.

Allergic: Rash Itching, facial edema, swelling, hive, blisters, erythema, and eosinophilia.

Respiratory: Tachypnea or hyperventilation, decrease in arterial PCO2.

Metabolic: Acidosis, Increase In serum chloride.

Accidental ingestion of SULFAMYLON Cream (mafenide acetate cream) has been reported to cause diarrhea.

Read the entire FDA prescribing information for Sulfamylon Cream (Mafenide Acetate Cream)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Women's Health

Find out what women really need.

Use Pill Finder Find it Now See Interactions

Pill Identifier on RxList

  • quick, easy,
    pill identification

Find a Local Pharmacy

  • including 24 hour, pharmacies

Interaction Checker

  • Check potential drug interactions
Search the Medical Dictionary for Health Definitions & Medical Abbreviations