home > drugs a-z list > sulfamylon (mafenide acetate) drug center > sulfamylon (mafenide acetate) drug - overdosage and contraindications

Recommended Topic Related To:

Sulfamylon

Introduction to burns

The skin has an important role to play in the fluid and temperature regulation of the body. If enough skin area is injured, the ability to maintain that control can be lost. The skin also acts as a protective barrier against the bacteria and viruses that inhabit the world outside the body.

The anatomy of the skin is complex, and there are many structures within the layers of the skin. There are three layers:

  1. Epidermis, the outer layer of the skin
  2. Dermis, made up of collagen and elastic fibers and where nerves, blood vessels, sweat glands, and hair follicles reside.
  3. Hypodermis or subcutaneous tissue, where larger blood vessels and nerves are located. This is the layer of tissue that is most important in temperature regulation.

The amount of damage that a burn can cause depends upon its location, its depth, and how much body surface area that it involves.

...

Sulfamylon

font size

OVERDOSE

Single oral doses of 2000 mg/kg of mafenide acetate as a 5% solution did not cause mortality or clinical symptoms of toxicity in rats.

CONTRAINDICATIONS

SULFAMYLON® (mafenide acetate) For 5% Topical Solution is contraindicated in patients who are hypersensitive to mafenide acetate. It is not known whether there is cross sensitivity to other sulfonamides.

Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Women's Health

Find out what women really need.