Supprelin LA (Histrelin Acetate Subcutaneous Implant) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 10, 2012

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Supprelin LA User Reviews >>

Supprelin LA

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Supprelin LA
(histrelin acetate) Subcutaneous Implant

DRUG DESCRIPTION

Supprelin LA (histrelin acetate) subcutaneous implant contains a synthetic nonapeptide analog of the naturally occurring gonadotropin releasing hormone (GnRH) that possesses a greater potency than the natural sequence hormone. The chemical name of histrelin acetate is:

L-Pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-N-benzyl-D-histidyl-L-leucyl-L-arginyl-L-proline Nethylamide, acetate salt.

The molecular formula for histrelin acetate is C66H86N18O12 x 2 CH3COOH and its molecular weight is 1443.70 (or 1323.52 as free base). Histrelin is also chemically described as 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-Lseryl- L-tyrosyl-Nt-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide diacetate. The chemical structure of the free base (histrelin) is represented below in Figure 1.

Figure 1. Structure of histrelin

Supprelin LA (histrelin acetate) Structural Formula Illustration

The Supprelin LA (histrelin acetate subcutaneous implant) implant looks like a small thin flexible tube. The sterile implant consists of a 50-mg histrelin acetate drug core inside a non-biodegradable, 3.5 cm by 3 mm, cylindrical hydrogel reservoir (Figure 2).

Figure 2. Histrelin Implant diagram (not to scale)

Histrelin Implant diagram - Illustration

The drug core also contains the inactive ingredient stearic acid NF. The hydrogel reservoir is a cartridge composed of 2-hydroxyethyl methacrylate, 2-hydroxypropyl methacrylate, trimethylolpropane trimethacrylate, benzoin methyl ether, Perkadox-16, and Triton X-100. Each hydrated implant is packaged in a glass vial containing 2 mL of 1.8% sodium chloride, sterile solution, so that it is primed for immediate release of the drug upon insertion. The 3.5 mL Type I clear glass vial with the implant is closed with a pre-treated grey Teflon coated stopper and sealed with an aluminum crimp seal.

A single use sterile insertion tool (Trocar) is to be used with Supprelin LA (histrelin acetate subcutaneous implant) . The insertion tool is enclosed in a sterile bag as part of the implantation kit.

What are the possible side effects of histrelin (Supprelin LA, Vantas)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

severe numbness or tingling in your legs or feet;
muscle weakness, problems with balance or coordination;
loss of bladder or bowel control;
urinating more or less than usual, or not at all;
fast or pounding heartbeats;
pale skin,...

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What are the precautions when taking histrelin acetate subcutaneous implant (Supprelin LA)?

Before using histrelin, tell your doctor or pharmacist if you are allergic to it; or to similar drugs (e.g., leuprolide); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: diabetes, heart disease (such as heart attack), stroke, family history of sudden cardiac death.

If you are a man using this medication for prostate cancer, histrelin may weaken your bones and increase your risk for bone loss (osteoporosis) if used for a long time. Before using this medication, tell your doctor or pharmacist if you have osteoporosis or if you have any of the...

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Last reviewed on RxList: 8/5/2008
This monograph has been modified to include the generic and brand name in many instances.