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The symptoms of overdosage of SUPRANE (desflurane) can present as a deepening of anesthesia, cardiac and/or respiratory depression in spontaneously breathing patients, and cardiac depression in ventilated patients in whom hypercapnia and hypoxia may occur only at a late stage. In the event of overdosage, or suspected overdosage, take the following actions: discontinue administration of SUPRANE (desflurane) , maintain a patent airway, initiate assisted or controlled ventilation with oxygen, and maintain adequate cardiovascular function.

The use of SUPRANE (desflurane) is contraindicated in the following conditions:

• Known or suspected genetic susceptibility to malignant hyperthermia.
• Patients in whom general anesthesia is contraindicated.
• Patients with known sensitivity to SUPRANE (desflurane) or to other halogenated agents [see WARNINGS AND PRECAUTIONS].

Last reviewed on RxList: 4/27/2010
This monograph has been modified to include the generic and brand name in many instances.