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The following adverse reactions are described, or described in greater detail, in other sections:
- Primary pulmonary hypertension [see WARNINGS AND PRECAUTIONS]
- Valvular heart disease [see WARNINGS AND PRECAUTIONS]
- Effect on the ability to engage in potentially hazardous tasks [see WARNINGS AND PRECAUTIONS]
- Withdrawal effects following prolonged high dosage administration [see Drug Abuse and Dependence]
The following adverse reactions to phentermine have been identified:
Primary pulmonary hypertension and/or regurgitant cardiac valvular disease, palpitation, tachycardia, elevation of blood pressure, ischemic events.
Central Nervous System
Dryness of the mouth, unpleasant taste, diarrhea, constipation, other gastrointestinal disturbances.
Read the Suprenza (phentermine hydrochloride) Side Effects Center for a complete guide to possible side effects »
Monoamine Oxidase Inhibitors
Use of Suprenza is contraindicated during or within 14 days following the administration of monoamine oxidase inhibitors because of the risk of hypertensive crisis.
Concomitant use of alcohol with Suprenza may result in an adverse drug reaction.
Insulin and Oral Hypoglycemic Medications
Requirements may be altered [see WARNINGS AND PRECAUTIONS].
Adrenergic Neuron Blocking Drugs
Suprenza may decrease the hypotensive effect of adrenergic neuron blocking drugs.
Drug Abuse And Dependence
Phentermine is a Schedule IV controlled substance.
Phentermine is related chemically and pharmacologically to the amphetamines. Amphetamines and other stimulant drugs have been extensively abused and the possibility of abuse of phentermine should be kept in mind when evaluating the desirability of including a drug as part of a weight reduction program.
Abuse of amphetamines and related drugs may be associated with intense psychological dependence and severe social dysfunction. There are reports of patients who have increased the dosage of these drugs to many times that recommended. Abrupt cessation following prolonged high dosage administration results in extreme fatigue and mental depression; changes are also noted on the sleep EEG. Manifestations of chronic intoxication with anorectic drugs include severe dermatoses, marked insomnia, irritability, hyperactivity and personality changes. A severe manifestation of chronic intoxication is psychosis, often clinically indistinguishable from schizophrenia.
Last reviewed on RxList: 1/3/2013
This monograph has been modified to include the generic and brand name in many instances.
Additional Suprenza Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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